Going nuclear: gene family evolution and vertebrate phylogeny reconciled

Cotton, J.A. and Page, R.D.M. (2002) Going nuclear: gene family evolution and vertebrate phylogeny reconciled. Proceedings of the Royal Society of London Series B: Biological Sciences, 269(1500), pp. 1555-1561. (doi:10.1098/rspb.2002.2074)

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Publisher's URL: http://dx.doi.org/10.1098/rspb.2002.2074

Abstract

Gene duplications have been common throughout vertebrate evolution, introducing paralogy and so complicating phylogenctic inference from nuclear genes. Reconciled trees are one method capable of dealing with paralogy, using the relationship between a gene phylogeny and the phylogeny of the organisms containing those genes to identify gene duplication events. This allows us to infer phylogenies from gene families containing both orthologous and paralogous copies. Vertebrate phylogeny is well understood from morphological and palaeontological data, but studies using mitochondrial sequence data have failed to reproduce this classical view. Reconciled tree analysis of a database of 118 vertebrate gene families supports a largely classical vertebrate phylogeny.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Page, Professor Roderic
Authors: Cotton, J.A., and Page, R.D.M.
Subjects:Q Science > QL Zoology
Q Science > QH Natural history > QH426 Genetics
College/School:College of Medical Veterinary and Life Sciences
Journal Name:Proceedings of the Royal Society of London Series B: Biological Sciences
Publisher:The Royal Society
ISSN:0962-8452
ISSN (Online):1471-2954
Copyright Holders:© Copyright The Royal Society
First Published:First published in Proceedings of the Royal Society of London Series B-Biological Sciences 269(1500):1555-1561
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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