A randomised controlled study of an audiovisual patient information intervention on informed consent and recruitment to cancer clinical trials

Hutchison, C., Cowan, C., McMahon, T. and Paul, J. (2007) A randomised controlled study of an audiovisual patient information intervention on informed consent and recruitment to cancer clinical trials. British Journal of Cancer, 97(6), pp. 705-711.

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Publisher's URL: http://www.nature.com/bjc/journal/v97/n6/full/6603943a.html

Abstract

Recruitment to cancer clinical trials needs to be improved, as does patient knowledge and understanding about clinical trials, in order for patients to make an informed choice about whether or not to take part. Audiovisual patient information (AVPI) has been shown to improve knowledge and understanding in various areas of practice, but there is limited information about its effect in the cancer clinical trial setting, particularly in relation to consent rates. In this study, 173 patients were randomised to receive either the AVPI, in addition to the standard trial-specific written information, or the written information alone. There was no difference in clinical trial recruitment rates between the two groups with similar study entry rates: 72.1% in the AVPI group and 75.9% in the standard information group. The estimated odds ratio for refusal (intervention/no intervention) was 1.19 (95% CI 0.55-2.58, P=0.661). Knowledge scores increased more in the AVPI group compared to the standard group (P=0.0072). The change in anxiety score between the arms was also statistically significant (P=0.011) with anxiety improving in the intervention arm more than in the no intervention arm. Audiovisual patient information was shown to be a useful tool in improving patient knowledge and anxiety, but further work is necessary in relation to its effect on clinical trial recruitment rates.

Item Type:Articles
Keywords:Cancer Clinical Trials; patient recruitment; audiovisual patient information; knowledge; understanding
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Paul, Mr James and Hutchison, Dr Catherine and McMahon, Mrs Tracey
Authors: Hutchison, C., Cowan, C., McMahon, T., and Paul, J.
Subjects:R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Research Group:Centre for Oncology & Applied Pharmacology
Journal Name:British Journal of Cancer
ISSN:0007-0912

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