Degraded diterpenoids from the stem bark of Neoboutonia mannii

Tene, M., Tane, P., Tamokou, J. D., Kuiate, J. R. and Connolly, J. D. (2008) Degraded diterpenoids from the stem bark of Neoboutonia mannii. Phytochemistry Letters, 1(2), pp. 120-124. (doi: 10.1016/j.phytol.2008.06.003)

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Abstract

Neoboutomannin (1), a degraded diterpenoid dimer, and manniorthoquinone (2), another degraded diterpenoid, have been isolated from the stem bark of Neoboutonia mannii Benth (Euphorbiaceae), together with the known 3-acetylaleuritolic acid (3), 3,6-dihydroxy-9-methoxy-1,7-dimethylphenanthrene (4) and sitosterol 3-O-beta-D-glucopyranoside (5). Their structures were elucidated on the basis of spectral studies and comparison with published data. Compounds 1, 3, 4 and 5 were evaluated for their antibacterial and antifungal activities. 1, 3 and 4 were active against Enterococcus faecalis, Staphylococcus aureus, Proteus mirabilis and three Candida species, Candida albicans ATCC 9002, Candida tropicalis and Candida parapsilosis. Compound 5 was inactive against all the bacterial and fungal species used..

Item Type:Articles
Keywords:ACID Antimicrobial activity Degraded diterpenoids Euphorbiaceae Manniorthoquinone Neoboutomannin Neoboutonia mannii Structure
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Connolly, Professor Joseph
Authors: Tene, M., Tane, P., Tamokou, J. D., Kuiate, J. R., and Connolly, J. D.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Phytochemistry Letters
ISSN:1874-3900

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