Tene, M., Tane, P., Tamokou, J. D., Kuiate, J. R. and Connolly, J. D. (2008) Degraded diterpenoids from the stem bark of Neoboutonia mannii. Phytochemistry Letters, 1(2), pp. 120-124. (doi: 10.1016/j.phytol.2008.06.003)
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Abstract
Neoboutomannin (1), a degraded diterpenoid dimer, and manniorthoquinone (2), another degraded diterpenoid, have been isolated from the stem bark of Neoboutonia mannii Benth (Euphorbiaceae), together with the known 3-acetylaleuritolic acid (3), 3,6-dihydroxy-9-methoxy-1,7-dimethylphenanthrene (4) and sitosterol 3-O-beta-D-glucopyranoside (5). Their structures were elucidated on the basis of spectral studies and comparison with published data. Compounds 1, 3, 4 and 5 were evaluated for their antibacterial and antifungal activities. 1, 3 and 4 were active against Enterococcus faecalis, Staphylococcus aureus, Proteus mirabilis and three Candida species, Candida albicans ATCC 9002, Candida tropicalis and Candida parapsilosis. Compound 5 was inactive against all the bacterial and fungal species used..
Item Type: | Articles |
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Keywords: | ACID Antimicrobial activity Degraded diterpenoids Euphorbiaceae Manniorthoquinone Neoboutomannin Neoboutonia mannii Structure |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Connolly, Professor Joseph |
Authors: | Tene, M., Tane, P., Tamokou, J. D., Kuiate, J. R., and Connolly, J. D. |
College/School: | College of Science and Engineering > School of Chemistry |
Journal Name: | Phytochemistry Letters |
ISSN: | 1874-3900 |
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