Anthocleistenolide, a new rearranged nor-secoirldoid derivative from the stem bark of Anthocleista vogelii

Tene, M., Tane, P., Kuiate, J. R., Tamokou, J. D. D. and Connolly, J. D. (2008) Anthocleistenolide, a new rearranged nor-secoirldoid derivative from the stem bark of Anthocleista vogelii. Planta Medica, 74(1), pp. 80-83.

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Abstract

A new rearranged nor-secoiridoid, anthocleistenolide (1), along with the known 1-hydroxy-3,7-dimethoxyxanthone (2), 1-hydroxy-3,7,8-trimethoxyxanthone (3), 7 alpha-hydroxysitosterol (4) and sitosterol 3-O-beta-D-glucopyranoside (5), were isolated from the stem bark of Anthocleista vogelii. Their structures were elucidated on the basis of spectral studies and comparison with published data. Compounds 1 - 3 and 5 were evaluated for their antibacterial and antifungal activities. Relatively low anti-staphylococcal (MIC=200 mu g/mL against Staphylococcus aureus) and anti-enterococcal (MIC = 100 mu g/mL against Enterococcus faecalis) activities were observed for 1, while compounds 2 and 3 were active against Candida parapsilosis (MIC = 200 mu g/mL for 2 and 25 mu g/mL for 3). Compound 5 was inactive against all the bacterial and fungal species used.

Item Type:Articles
Keywords:Anthocleista vogehi anthocleistenolide Antimicrobial activity BARK CONSTITUENTS ENTEROCOCCUS-FAECALIS Gentianaceae GLUCOSIDES IRIDOIDS nor-secoiricloid PLANTS Structure xanthones
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Connolly, Professor Joseph
Authors: Tene, M., Tane, P., Kuiate, J. R., Tamokou, J. D. D., and Connolly, J. D.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Planta Medica
ISSN:0032-0943

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