Tene, M., Tane, P., Kuiate, J. R., Tamokou, J. D. D. and Connolly, J. D. (2008) Anthocleistenolide, a new rearranged nor-secoirldoid derivative from the stem bark of Anthocleista vogelii. Planta Medica, 74(1), pp. 80-83.
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Abstract
A new rearranged nor-secoiridoid, anthocleistenolide (1), along with the known 1-hydroxy-3,7-dimethoxyxanthone (2), 1-hydroxy-3,7,8-trimethoxyxanthone (3), 7 alpha-hydroxysitosterol (4) and sitosterol 3-O-beta-D-glucopyranoside (5), were isolated from the stem bark of Anthocleista vogelii. Their structures were elucidated on the basis of spectral studies and comparison with published data. Compounds 1 - 3 and 5 were evaluated for their antibacterial and antifungal activities. Relatively low anti-staphylococcal (MIC=200 mu g/mL against Staphylococcus aureus) and anti-enterococcal (MIC = 100 mu g/mL against Enterococcus faecalis) activities were observed for 1, while compounds 2 and 3 were active against Candida parapsilosis (MIC = 200 mu g/mL for 2 and 25 mu g/mL for 3). Compound 5 was inactive against all the bacterial and fungal species used.
Item Type: | Articles |
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Keywords: | Anthocleista vogehi anthocleistenolide Antimicrobial activity BARK CONSTITUENTS ENTEROCOCCUS-FAECALIS Gentianaceae GLUCOSIDES IRIDOIDS nor-secoiricloid PLANTS Structure xanthones |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Connolly, Professor Joseph |
Authors: | Tene, M., Tane, P., Kuiate, J. R., Tamokou, J. D. D., and Connolly, J. D. |
College/School: | College of Science and Engineering > School of Chemistry |
Journal Name: | Planta Medica |
ISSN: | 0032-0943 |
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