Stambasky, J., Malkov, A. V. and Kocovsky, P. (2008) Synthesis of Enantiopure 1-Arylprop-2-en-1-ols and Their tert-Butyl Carbonates. Journal of Organic Chemistry, 73(22), pp. 9148-9150. (doi: 10.1021/jo801874r)
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Abstract
Enantiomerically pure 1-arylpropenols 8 have been prepared by resolution of the corresponding racemates, using the lipase formulation Novozyme 435. Deprotonation of the latter alcohols with n-BuLi, followed by derivatization with (t-BUO)(2)CO, afforded the corresponding carbonates 5. Optimization of the process is presented.
| Item Type: | Articles |
|---|---|
| Keywords: | 1ST OBSERVATION ALCOHOLS ALKOXIDES ASYMMETRIC-SYNTHESIS Carbonates CATALYZED ALLYLIC ALKYLATION COMPLEXES DICHOTOMY ETHERIFICATION MEMORY Molybdenum OPTIMIZATION RESOLUTION SUBSTITUTION |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Malkov, Dr Andrei and Kocovsky, Professor Pavel |
| Authors: | Stambasky, J., Malkov, A. V., and Kocovsky, P. |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | Journal of Organic Chemistry |
| ISSN: | 0022-3263 |
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