Micropatterned Surfaces with Covalently Grafted Unsymmetrical Polyoxometalate-Hybrid Clusters Lead to Selective Cell Adhesion

Song, Y.F., McMillan, N., Long, D.L. , Kane, S., Malm, J., Riehle, M. , Pradeep, C.P., Gadegaard, N. and Cronin, L. (2009) Micropatterned Surfaces with Covalently Grafted Unsymmetrical Polyoxometalate-Hybrid Clusters Lead to Selective Cell Adhesion. Journal of the American Chemical Society, 131(4), pp. 1340-1341. (doi:10.1021/ja807091v)

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Publisher's URL: http://dx.doi.org/10.1021/ja807091v

Abstract

Mn-Anderson based polyoxometalate clusters with different terminal groups have been patterned successfully onto self-assembled monolayer (SAM) using microcontact printing. Studies of the interactions between the designed SAMs and human fibroblast (hTERT-BJ1) cells have been reported, and it was observed that cells attach and spread efficiently for monolayer presenting a terminal aromatic pyrene platform with a polyoxometalate Mn-Anderson cluster as linker, demonstrating the crucial role played by the polyoxometalate metal oxide cluster as an intermediary in cell adhesion to the surface.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Riehle, Dr Mathis and Gadegaard, Professor Nikolaj and Long, Dr De Liang and Cronin, Professor Leroy
Authors: Song, Y.F., McMillan, N., Long, D.L., Kane, S., Malm, J., Riehle, M., Pradeep, C.P., Gadegaard, N., and Cronin, L.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
College of Science and Engineering > School of Chemistry
College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Journal of the American Chemical Society
ISSN:0002-7863
ISSN (Online):1520-5126
Published Online:12 January 2009

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
456571Directly reconfigurable nanomachinesLeroy CroninEngineering & Physical Sciences Research Council (EPSRC)EP/F009410/1Chemistry