Trypanocidal labdane diterpenoids from the seeds of Aframomum aulacocarpos (Zingiberaceae)

Sob, S. V. T., Tane, P., Ngadjui, B. T., Connolly, J. D. and Ma, D. (2007) Trypanocidal labdane diterpenoids from the seeds of Aframomum aulacocarpos (Zingiberaceae). Tetrahedron, 63(36), pp. 8993-8998. (doi: 10.1016/j.tet.2007.05.120)

Abstract

Two novel labdane type diterpenoids, 8 beta(17)-epoxy-14,15,16-trihydroxylabd-12(E)-ene (aulacocarpin C) and 15,16-epoxy-14 xi, 16 xi-dimethoxylabda-8(17), 12-(E)-diene (aulacocarpin D) together with the known aulacocarpin A and B; 14,15-epoxy-8(17), 12(E)-labdadien- 16-al, coronarin E, and 15,16-epoxy-12 beta-hydroxy-labda-8(17)-13(16), 14-triene were isolated from the seeds of Aframomum aulacocarpos. To the best of our knowledge, the last compound was isolated from a natural source for the first time. Acid hydrolysis of aulacocarpin D led to another new labdane type diterpenoid, 15,16-epoxy-12 beta-methoxylabda-8(17)-13(16), 14-triene. The structures of all compounds were established on the basis of their spectroscopic data. These new compounds exhibit moderate trypanocidal activity..

• Item Type: Articles
• Keywords: (+)-CORONARIN E ACID Aframomum aulacocarpos aulacocarpin BIOACTIVE DITERPENOIDS HYDROLYSIS labdane diterpenoids NMR SEEDS Structure trypanocidal Zingiberaceae
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Connolly, Professor Joseph
• Authors: Sob, S. V. T., Tane, P., Ngadjui, B. T., Connolly, J. D., and Ma, D.
• College/School: College of Science and Engineering > School of Chemistry
• Journal Name: Tetrahedron
• ISSN: 0040-4020