One-pot synthesis of dihydroimidazo- and imidazophenanthridinium salts

Parenty, A. D. C. and Cronin, L. (2008) One-pot synthesis of dihydroimidazo- and imidazophenanthridinium salts. Synthesis(1), pp. 155-160. (doi: 10.1055/s-2007-983895)

Abstract

Two highly efficient and general one-pot annulation reactions are described for the synthesis of dihydroimidazo- and imidazophenanthridinium salts (DIPs(+) and IPs(+)). These two methodologies exploit the difference in reactivity between primary amino-based or ammonia nucleophiles and the dielectrophilic starting material, 2-bromoethylphenanthridinium bromide.

• Item Type: Articles
• Keywords: Ammonia annulation annulation reaction anticancer agents BROMIDE DIFFERENCE DNA intercalating agents DNA-BINDING AGENTS DUPLEX DNA EFFICIENT HETEROCYCLES MOLECULES ONE-POT phenanthridinium derivatives PLATINUM PHENANTHRIDINIUM COMPLEXES REACTIVITY RING SALT
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Parenty, Mr Alexis and Cronin, Professor Lee
• Authors: Parenty, A. D. C., and Cronin, L.
• College/School: College of Science and Engineering > School of Chemistry
• Journal Name: Synthesis
• ISSN: 0039-7881
• ISSN (Online): 1437-210X