Comparative study of the constitution and chiroptical properties of emissive terbium and europium complexes with a common tetraazatriphenylene sensitiser; the nature of the sensitiser determines quenching sensitivity and cellular uptake

New, E. J., Parker, D. and Peacock, R. D. (2009) Comparative study of the constitution and chiroptical properties of emissive terbium and europium complexes with a common tetraazatriphenylene sensitiser; the nature of the sensitiser determines quenching sensitivity and cellular uptake. Dalton Transactions(4), pp. 672-679. (doi: 10.1039/b816173a)

Abstract

Six pairs of Eu(III) and Tb(III) complexes of macrocyclic ligands, incorporating a common tetraazatriphenylene sensitiser, have been examined in terms of their solution structure, sensitivity to excited state quenching, protein affinity, cell toxicity and preliminary cell localisation profiles. A complex with three (S)-phenylalanine-derived ligating groups possesses distinctive H-1 NMR, Eu emission and circularly polarised emission properties, consistent with a unique Lambda-configuration in the 9-coordinate complex, where an amide carbonyl group occupies the capping position of the coordination polyhedron. Each complex possesses similar sensitivity to quenching by ascorbate, urate and iodide, has similar toxicity behaviour and shows a common intracellular localisation pro. le that is consistent with compartmentalisation in lysosomes or late endosomes. Such behaviour accords with the hypothesis that it is the nature of the sensitising moiety that determines each of these properties.

• Item Type: Articles
• Keywords: ANTIOXIDANTS CELL COMPLEX COMPLEXES CONSTITUTION COORDINATION DYNAMICS Europium IN-VITRO LANTHANIDE COMPLEXES LIGAND LIGANDS LIVING CELLS Luminescence MACROCYCLIC LIGANDS NMR OPTICAL PROBES PH PROFILE PROTEIN PROTEIN AFFINITY REVERSIBLE BINDING STATE Structure
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Peacock, Dr Robert
• Authors: New, E. J., Parker, D., and Peacock, R. D.
• College/School: College of Science and Engineering > School of Chemistry
• Journal Name: Dalton Transactions
• ISSN: 1477-9226