Malkov, A. V., Vrankova, K., Sigerson, R. C., Stoncius, S. and Kocovsky, P. (2009) New organocatalysts for the asymmetric reduction of imines with trichlorosilane. Tetrahedron, 65(45), pp. 9481-9486. (doi: 10.1016/j.tet.2009.08.048)
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Abstract
Asymmetric reduction of prochiral ketimines 1a-f with trichlorosilane can be catalyzed by the Lewis-basic formamides (S)-4a,b, derived from N-methyl valine, with <91% enantioselectivity and low catalyst loading (<= 5 mol %) at room temperature in toluene. .
| Item Type: | Articles |
|---|---|
| Keywords: | AMINO ACID-DERIVATIVES Asymmetric catalysis Asymmetric reduction CATALYZED TRANSFER HYDROGENATION DYNAMIC KINETIC RESOLUTION Enantioselective reduction EXPERIMENTAL SUPPORT HIGHLY ENANTIOSELECTIVE HYDROGENATION Hydrosilylation HYDROXYCYCLOPENTADIENYL RUTHENIUM HYDRIDE IR-F-BINAPHANE Lewis-basic catalysts N-ARYL IMINES Organocatalysis ORGANOCATALYSTS REDUCTION ROOM-TEMPERATURE STEREOSELECTIVE REDUCTION TEMPERATURE Trichlorosilane UNPRECEDENTED SUBSTRATE PROFILE |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Malkov, Dr Andrei and Stoncius, Mr Sigitas and Kocovsky, Professor Pavel |
| Authors: | Malkov, A. V., Vrankova, K., Sigerson, R. C., Stoncius, S., and Kocovsky, P. |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | Tetrahedron |
| ISSN: | 0040-4020 |
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