Malkov, A. V., Figlus, M., Prestly, M. R., Rabani, G., Cooke, G. and Kocovsky, P. (2009) Soluble Polymer-Supported Organocatalysts: Asymmetric Reduction of Imines with Trichlorosilane Catalyzed by an Amino Acid Derived Formamide Anchored to a Soluble Polymer. Chemistry: A European Journal, 15(38), pp. 9651-9654. (doi: 10.1002/chem.200901573)
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Publisher's URL: http://dx.doi.org/10.1002/chem.200901573
Abstract
A novel polymeric platform for catalyst immobilization has been developed, featuring inverted solubility pattern: soluble in a nonpolar and insoluble in a polar medium. Asymmetric reduction of imines with Cl<sub>3</sub>SiH (see scheme), catalyzed by chiral formamide anchored to this soluble polymer, proceeds under homogeneous conditions to give chiral amines in high yields and enantioselectivities (≤91 % ee).
| Item Type: | Articles |
|---|---|
| Keywords: | ACID AMINATION AROMATIC KETIMINES Asymmetric reduction asymmetric synthesis DYNAMIC KINETIC RESOLUTION Enantioselective reduction IMINES N-ARYL IMINES ORGANIC ACTIVATORS Organocatalysis ORGANOCATALYSTS polymer-supported catalysts POLYMER-SUPPORTED ORGANOCATALYSTS RADICAL POLYMERIZATION RECOVERABLE CATALYSTS REDUCTION STEREOSELECTIVE REDUCTION TRANSFER HYDROGENATION Trichlorosilane. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Malkov, Dr Andrei and Cooke, Professor Graeme and Rabani, Dr Gouher and Figlus, Mr Marek and Kocovsky, Professor Pavel |
| Authors: | Malkov, A. V., Figlus, M., Prestly, M. R., Rabani, G., Cooke, G., and Kocovsky, P. |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | Chemistry: A European Journal |
| Journal Abbr.: | Chem. Eur J. |
| Publisher: | Wiley-VCH Verlag |
| ISSN: | 0947-6539 |
| ISSN (Online): | 1521-3765 |
| Published Online: | 26 August 2009 |
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