Malkov, A. V., Figlus, M., Cooke, G. , Caldwell, S.T. , Rabani, G., Prestly, M. R. and Kocovsky, P. (2009) Organocatalysts immobilised onto gold nanoparticles: application in the asymmetric reduction of imines with trichlorosilane. Organic and Biomolecular Chemistry, 7(9), pp. 1878-1883. (doi: 10.1039/b821391g)
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Abstract
Gold nanoparticles functionalised with a valine-derived formamide have been developed as effective homogenous catalysts for the asymmetric reduction of ketimine 1 with trichlorosilane (<= 84% ee) in toluene. This methodology both simplifies the recovery of the catalyst and its separation from the product, as the nanoparticles can be readily removed and subsequently recycled by precipitation from the reaction mixture.
| Item Type: | Articles |
|---|---|
| Keywords: | AMINATION AROMATIC KETIMINES Asymmetric reduction CASCADE CATALYST CATALYSTS DERIVATIVES Enantioselective reduction FORMAMIDES Gold Hydrosilylation IMINES N-ARYL IMINES ORGANOCATALYSTS REDUCTION TRANSFER HYDROGENATION Trichlorosilane |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Caldwell, Dr Stuart and Malkov, Dr Andrei and Cooke, Professor Graeme and Rabani, Dr Gouher and Figlus, Mr Marek and Kocovsky, Professor Pavel |
| Authors: | Malkov, A. V., Figlus, M., Cooke, G., Caldwell, S.T., Rabani, G., Prestly, M. R., and Kocovsky, P. |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | Organic and Biomolecular Chemistry |
| ISSN: | 1477-0520 |
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