Tetrathiafulvalene end-functionalized poly(N-isopropylacrylamide): a new class of amphiphilic polymer for the creation of multistimuli responsive micelles

Bigot, J., Charleux, B., Cooke, G. , Delattre, F., Fournier, D., Lyskawa, J., Sambe, L., Stoffelbach, F. and Woisel, P. (2010) Tetrathiafulvalene end-functionalized poly(N-isopropylacrylamide): a new class of amphiphilic polymer for the creation of multistimuli responsive micelles. Journal of the American Chemical Society, 132(31), pp. 10796-10801. (doi:10.1021/ja1027452)

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Abstract

In this article, we report the formation of micelles from a tetrathiafulvalene (TTF) end-functionalized poly(N-isopropylacrylamide) (poly(NIPAM)) derivative (1). We have determined the critical aggregation concentration (CAC) and average diameter of the micelles using fluorescence spectroscopy and dynamic light scattering experiments, respectively. We have exploited the NIPAM backbone of the polymer to thermally transform the swollen hydrophilic poly(NIPAM) derivative to a more globular hydrophobic state at the lower critical solution temperature (LCST). Finally, we have shown that we can exploit the chemical oxidation and complexation properties of the TTF unit to disrupt the micelle architecture to release the hydrophobic dye Nile Red from the interior of the micelle.

Item Type:Articles
Keywords:AQUEOUS-SOLUTIONS BETA-CYCLODEXTRIN BLOCK-COPOLYMER ASSEMBLIES BUILDING-BLOCKS DRUG-DELIVERY ELECTRON-TRANSFER HOST-GUEST INTERACTIONS N-ISOPROPYLACRYLAMIDE OXIDATION PHASE-TRANSITION REDOX STATE
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cooke, Professor Graeme
Authors: Bigot, J., Charleux, B., Cooke, G., Delattre, F., Fournier, D., Lyskawa, J., Sambe, L., Stoffelbach, F., and Woisel, P.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Journal of the American Chemical Society
ISSN:0002-7863

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