Zile, M. R. et al. (2010) Mode of Death in Patients With Heart Failure and a Preserved Ejection Fraction Results From the Irbesartan in Heart Failure With Preserved Ejection Fraction Study (I-Preserve) Trial. Circulation, 121(12), pp. 1393-1405. (doi: 10.1161/CIRCULATIONAHA.109.909614)
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Abstract
Background-The mode of death has been well characterized in patients with heart failure and a reduced ejection fraction; however, less is known about the mode of death in patients with heart failure and a preserved ejection fraction (HFPEF). The purpose of this study was to examine the mode of death in patients with HFPEF enrolled in the Irbesartan in Heart Failure With Preserved Ejection Fraction Study (I-Preserve) trial and to determine whether irbesartan altered the distribution of mode of death in HFPEF. Methods and Results-All deaths were reviewed by a clinical end-point committee, and the mode of death was assigned by consensus of the members. The annual mortality rate was 5.2% in the I-Preserve trial. There were no significant differences in mortality rate between the placebo and irbesartan groups. The mode of death was cardiovascular in 60% (including 26% sudden, 14% heart failure, 5% myocardial infarction, and 9% stroke), noncardiovascular in 30%, and unknown in 10%. There were no differences in the distribution of mode-specific mortality rates between placebo and irbesartan. Conclusions-Sixty percent of the deaths in patients with HFPEF were cardiovascular, with sudden death and heart failure death being the most common. Treatment with irbesartan did not affect overall mortality or the distribution of mode-specific mortality rates. Clinical Trial Registration-URL: http://www.clinicaltrials.gov. Unique identifier: NCT00095238. (Circulation. 2010; 121: 1393-1405.)
| Item Type: | Articles |
|---|---|
| Keywords: | cardiac death CARDIAC-RESYNCHRONIZATION THERAPY CARVEDILOL CLINICAL CHARACTERISTICS DEATH death,sudden DEATHS DISEASE EJECTION FRACTION ENALAPRIL FAILURE HEART Heart failure HEART-FAILURE INFARCTION irbesartan ISOSORBIDE DINITRATE LEFT-VENTRICLE MORBIDITY MORTALITY Myocardial infarction MYOCARDIAL-INFARCTION PATIENT patients stroke SYSTOLIC FUNCTION Treatment TRIAL VASODILATOR THERAPY ventricular ejection fraction |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | McMurray, Professor John |
| Authors: | Zile, M. R., Gaasch, W. H., Anand, I. S., Haass, M., Little, W. C., Miller, A. B., Lopez-Sendon, J., Teerlink, J. R., White, M., McMurray, J.J., Komajda, M., McKelvie, R., Ptaszynska, A., Hetzel, S. J., Massie, B. M., and Carson, P. E. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences |
| Journal Name: | Circulation |
| ISSN: | 0009-7322 |
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