Biomarkers in heart failure: a clinical review

Rocchiccioli, J.P., McMurray, J.J.V. and Dominiczak, A.F. (2010) Biomarkers in heart failure: a clinical review. Heart Failure Reviews, 15(4), pp. 251-273. (doi:10.1007/s10741-008-9123-9)

Rocchiccioli, J.P., McMurray, J.J.V. and Dominiczak, A.F. (2010) Biomarkers in heart failure: a clinical review. Heart Failure Reviews, 15(4), pp. 251-273. (doi:10.1007/s10741-008-9123-9)

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Abstract

The diagnosis and management of heart failure remains challenging despite considerable clinical advances in recent decades. With greater understanding of the pathophysiology of this complex syndrome, a large number of candidate biomarkers have emerged and duly received scientific and clinical attention. These are frequently a measure of the degree of pathophysiological derangement or counter-regulatory processes occurring in heart failure and include biomarkers of neurohormonal activation, myocyte necrosis and myocardial remodelling amongst others. As such they may serve as an indicator of the presence, severity and possibly therapeutic response of the heart failure syndrome and may complement conventional clinical measurements and acumen. This may in turn lead to tangible clinical benefits and the targeting of intensified and often costly therapies to those most at risk. This article reviews and summarises the most extensively investigated biomarkers currently available, with an emphasis on clinical applicability and discusses the future evaluation of candidate biomarkers in patients with heart failure

Item Type:Articles
Keywords:ACID-BINDING PROTEIN ACTIVATION ACUTE CORONARY SYNDROMES ACUTE MYOCARDIAL-INFARCTION advances Attention BENEFITS BIOMARKERS BRAIN NATRIURETIC PEPTIDE C-REACTIVE PROTEIN CANCER CARDIAC TROPONIN-T CARDIOVASCULAR RISK-FACTORS COMPLEXES CYTOKINE DIAGNOSIS EMERGENCY-DEPARTMENT PRIDE FAILURE HEART Heart failure HEART-FAILURE hypertension INDICATOR Kidney LEFT-VENTRICULAR DYSFUNCTION LIFE MANAGEMENT Measurement MS NECROSIS-FACTOR-ALPHA NEUROHORMONAL ACTIVATION Neurohormones NUMBER PATIENT patients PEPTIDE Remodelling RISK RISK STRATIFICATION Scotland SEVERITY Syndrome SYSTEM SYSTEMS THERAPIES THERAPY
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Rocchiccioli, Dr John and McMurray, Professor John and Dominiczak, Professor Anna
Authors: Rocchiccioli, J.P., McMurray, J.J.V., and Dominiczak, A.F.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences
Journal Name:Heart Failure Reviews
ISSN:1382-4147

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