The effects of uterine artery embolisation and surgical treatment on ovarian function in women with uterine fibroids

Rashid, S., Khaund, A., Murray, L., Moss, J.G., Cooper, K., Lyons, D., Murray, G.D. and Lumsden, M.A. (2010) The effects of uterine artery embolisation and surgical treatment on ovarian function in women with uterine fibroids. BJOG: An International Journal of Obstetrics and Gynaecology, 117(8), pp. 985-989. (doi: 10.1111/j.1471-0528.2010.02579.x)

Abstract

Objective The aim of this study was to evaluate and compare both ovarian function and menstrual characteristics following uterine artery embolisation (UAE) and surgery. Design Subgroup of women from a randomised controlled trial. Setting Gynaecology and radiology units in Scotland, UK. Population Ninety-six women from the randomised controlled trial comparing embolisation with surgery as a treatment for fibroids (REST), which recruited 157 patients (106 UAE; 51 surgery). Methods Seventy-three women undergoing UAE and 23 women undergoing surgery (with ovarian conservation) had serum follicle-stimulating hormone (FSH) measurements taken on day 3 of the menstrual cycle prior to treatment, and at 6 and 12 months post-treatment. Data on menstrual cycle characteristics was also collected. Main outcome measures Ovarian failure, as defined by an FSH level of > 40 iu/l, and change in duration of menses and length of menstrual cycle. Results There was no significant difference in the rate of ovarian failure at 12 months between UAE (11%) and surgical patients (18%) (P = 0.44). This finding was not influenced by age. The mean duration of menstrual flow decreased significantly, from baseline to 12 months, by 1.7 days (SD 3.8), (95% CI 0.8-2.6). There was no statistically significant change in mean cycle length at 12 months (0.7 days [SD 4.9]; 95% CI [-0.5, 1.9]). Conclusions There is no evidence for UAE accelerating a deterioration in ovarian function at 1 year, when compared with surgery. UAE is associated with a decrease in the duration of menstrual flow at 1 year

• Item Type: Articles
• Additional Information: The definitive version is available at www3.interscience.wiley.com
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Murray, Ms Gillian and Murray, Dr Lilian and Lumsden, Professor Mary
• Authors: Rashid, S., Khaund, A., Murray, L., Moss, J.G., Cooper, K., Lyons, D., Murray, G.D., and Lumsden, M.A.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities
• Journal Name: BJOG: An International Journal of Obstetrics and Gynaecology
• Publisher: Wiley-Blackwell Publishing Ltd.
• ISSN: 1470-0328
• ISSN (Online): 1471-0528
• Published Online: 11 May 2010
• Copyright Holders: Copyright © 2010 RCOG
• First Published: First published in BJOG: An International Journal of Obstetrics and Gynaecology 117(8):985-989
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher