Our Current Understanding of Fungal Biofilms

Ramage, G. , Mowat, E., Jones, B., Williams, C. and Lopez-Ribot, J. (2009) Our Current Understanding of Fungal Biofilms. Critical Reviews in Microbiology, 35(4), pp. 340-355. (doi:10.3109/10408410903241436)

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Abstract

Fungal biofilms are an escalating clinical problem associated with significant rates of mortality. Candida albicans is the most notorious of all fungal biofilm formers. However, non-Candida species, yeasts such as Cryptococcus neoformans, and filamentous moulds such as Aspergillus fumigatus, have been shown to be implicated in biofilm-associated infections. Fungal biofilms have distinct developmental phases, including adhesion, colonisation, maturation and dispersal, which are governed by complex molecular events. Recalcitrance to antifungal therapy remains the greatest threat to patients with fungal biofilms. This review discusses our current understanding of the basic biology and clinical implications associated with fungal biofilms

Item Type:Articles
Keywords:antifungal, antifungal agents, aspergillus, biofilm, biology, candida, candida-albicans biofilms, central venous catheter, cryptococcus, cryptococcus-neoformans, events, fungi, human epithelial-cells, in-vitro activity, infection, innate immune-system, maturation, mortality, quorum-sensing molecule, secreted aspartyl proteinase, therapy, tolerant persister cells
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ramage, Professor Gordon
Authors: Ramage, G., Mowat, E., Jones, B., Williams, C., and Lopez-Ribot, J.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
Journal Name:Critical Reviews in Microbiology
ISSN:1040-841X

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