Rafnsson, S., Deary, I.J., Whiteman, M.C., Rumley, A., Lowe, G.D.O. and Fowkes, F.G.R. (2010) Haemorheological predictors of cognitive decline: the Edinburgh Artery Study. Age and Ageing, 39(2), pp. 217-222. (doi: 10.1093/ageing/afp227)
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Abstract
Methods: blood rheology data were collected in 1987/88, and cognitive testing was performed in 1998/99 when the mean (+/- standard deviation) age of the study sample was 73.1 years (+/- 5.0). Follow-up assessment was performed 4 years later. Information was collected on verbal declarative memory, non-verbal reasoning, verbal fluency, information processing speed and a general cognitive factor representing the variance common to the individual test scores. Results: after controlling for age, sex and cognitive performance in 1998/99, blood viscosity (BV) (P < 0.05) and fibrinogen (P < 0.05) predicted decline in non-verbal reasoning over 4 years. When estimated from pre-morbid level, decline in general cognition (P < 0.05), non-verbal reasoning (P < 0.05) and information processing speed (P < 0.01) was associated with BV levels. Haematocrit (HCT) had similar effects (P < 0.01 to P < 0.001). All associations persisted after control for multiple confounders. When examined together, HCT but not BV independently predicted cognitive decline. Conclusions: blood rheology is independently related to cognitive decline in older people. The value of strategies aimed at preserving cognition through influencing blood rheology needs investigation
| Item Type: | Articles |
|---|---|
| Keywords: | AGE aged Aging ASSOCIATION BLOOD-VISCOSITY bloodviscosity CARDIOVASCULAR-DISEASES cognition elderly FOLLOW-UP haematocrit haemorheology Impairment LEVEL MEN OLDER-PEOPLE PERFORMANCE POPULATION RHEOLOGY RISK-FACTORS SCORE STENOSIS stroke VASCULAR DEMENTIA |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Lowe, Professor Gordon |
| Authors: | Rafnsson, S., Deary, I.J., Whiteman, M.C., Rumley, A., Lowe, G.D.O., and Fowkes, F.G.R. |
| College/School: | College of Medical Veterinary and Life Sciences |
| Journal Name: | Age and Ageing |
| Publisher: | Oxford University Press |
| ISSN: | 0002-0729 |
| ISSN (Online): | 1468-2834 |
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