Enlighten
Research publications by members of the University of Glasgow
home > services > Enlighten

Analysis of the spectrotypes of autoantibodies against thyroglobulin in two rat models of autoimmune thyroiditis

Stott, D.I., Hassman, R., Neilson, L., and McGregor, A.M. (1988) Analysis of the spectrotypes of autoantibodies against thyroglobulin in two rat models of autoimmune thyroiditis. Clinical and Experimental Immunology, 73 (2). pp. 269-275. ISSN 0009-9104

[img] Text
pubmedredirect.html

4Kb

Abstract

We have studied the isoelectric focusing (IEF) spectrotypes of autoantibodies against thyroglobulin in two rat models of Hashimoto's thyroiditis: (1) AUG strain rats immunized with autologous thyroglobulin in Freund's complete adjuvant; (2) PVG/c strain rats which have been thymectomized and sublethally irradiated. The IEF spectrotypes revealed differences between the two models. The anti-thyroglobulin response in immunized AUG rats is mainly oligoclonal or polyclonal, often with dominant clones in the spectrotype, similar to about 90% of Hashimoto's patients, whereas the response in the PVG/c rat is highly restricted. There were pronounced changes in spectrotype with time in the PVG/c, but not AUG, rats with considerable variation in the lifespan of individual clones. The maximum lifespan of an anti-self secreting B-cell clone in the PVG/c rat, determined by persistence of its clonotype, was at least 16 weeks.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s):Stott, Prof David
Authors: Stott, D.I., Hassman, R., Neilson, L., and McGregor, A.M.
Subjects:Q Science > QR Microbiology > QR180 Immunology
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Clinical and Experimental Immunology
Publisher:Wiley-Blackwell Publishing Ltd.
ISSN:0009-9104

University Staff: Request a correction | Enlighten Editors: Update this record

Downloads per month over past year

View more statistics