Nijs, J., Van Oosterwijck, J., Meeus, M., Lambrecht, L., Metzger, K., Fremont, M. and Paul, L. (2010) Unravelling the nature of postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: the role of elastase, complement C4a and interleukin-1 beta. Journal of Internal Medicine, 267(4), pp. 418-435. (doi: 10.1111/j.1365-2796.2009.02178.x)
Full text not currently available from Enlighten.
Abstract
Nijs J, Van Oosterwijck J, Meeus M, Lambrecht L, Metzger K, Fremont M, Paul L (Vrije Universiteit Brussel, Brussels; University College Antwerp, Antwerp; University Hospital Brussels, Brussels; Private Practice for Internal Medicine, Gent/Aalst; and RED Laboratories N.V., Zellik; Belgium, and University of Glasgow, Glasgow, UK). Unravelling the nature of postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: the role of elastase, complement C4a and interleukin-1 beta. J Intern Med 2010; 267: 418-435. Objectives. Too vigorous exercise or activity increase frequently triggers postexertional malaise in people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a primary characteristic evident in up to 95% of people with ME/CFS. The present study aimed at examining whether two different types of exercise results in changes in health status, circulating elastase activity, interleukin (IL)-1 beta and complement C4a levels. Design. Comparative experimental design. Setting. University. Subjects. Twenty-two women with ME/CFS and 22 healthy sedentary controls Interventions: participants were subjected to a submaximal exercise (day 8) and a self-paced, physiologically limited exercise (day 16). Each bout of exercise was preceded and followed by blood sampling, actigraphy and assessment of their health status. Results. Both submaximal exercise and self-paced, physiologically limited exercise resulted in postexertional malaise in people with ME/CFS. However, neither exercise bout altered elastase activity, IL-1 beta or complement C4a split product levels in people with ME/CFS or healthy sedentary control subjects (P > 0.05). Postexercise complement C4a level was identified as a clinically important biomarker for postexertional malaise in people with ME/CFS. Conclusions. Submaximal exercise as well as self-paced, physiologically limited exercise triggers postexertional malaise in people with ME/CFS, but neither types of exercise alter acute circulating levels of IL-1 beta, complement C4a split product or elastase activity. Further studying of immune alterations in relation to postexertional malaise in people with ME/CFS using multiple measurement points postexercise is required
| Item Type: | Articles |
|---|---|
| Keywords: | allergy BLOOD CARE Chronic chronic fatigue syndrome DEFINITION DESIGN exercise fibromyalgia GRADED-EXERCISE HEALTH Human IMMUNE DYSFUNCTION immunity IN-VIVO INCREASE INTERVENTION LEVEL Measurement Oxidative stress PAIN PEOPLE PERFORMANCE postexertional malaise PRODUCT RANDOMIZED CONTROLLED-TRIAL RELIABILITY RESPONSES Survey WOMEN |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Paul, Dr Lorna |
| Authors: | Nijs, J., Van Oosterwijck, J., Meeus, M., Lambrecht, L., Metzger, K., Fremont, M., and Paul, L. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Nursing and Health Care |
| Journal Name: | Journal of Internal Medicine |
| ISSN: | 0954-6820 |
University Staff: Request a correction | Enlighten Editors: Update this record
Altmetric
Altmetric