Maternal metabolism and obesity: modifiable determinants of pregnancy outcome

Nelson, S. M. , Matthews, P. and Poston, L. (2010) Maternal metabolism and obesity: modifiable determinants of pregnancy outcome. Human Reproduction Update, 16(3), pp. 255-275. (doi:10.1093/humupd/dmp050)

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Abstract

BACKGROUND: Obesity among pregnant women is highly prevalent worldwide and is associated in a linear manner with markedly increased risk of adverse outcome for mother and infant. Obesity in the mother may also independently confer risk of obesity to her child. The role of maternal metabolism in determining these outcomes and the potential for lifestyle modification are largely unknown. METHODS: Relevant studies were identified by searching PubMed, the metaRegister of clinical trials and Google Scholar without limitations. Sensitive search strategies were combined with relevant medical subject headings and text words. RESULTS: Maternal obesity and gestational weight gain have a significant impact on maternal metabolism and offspring development. Insulin resistance, glucose homeostasis, fat oxidation and amino acid synthesis are all disrupted by maternal obesity and contribute to adverse outcomes. Modification of lifestyle is an effective intervention strategy for improvement of maternal metabolism and the prevention of type 2 diabetes and, potentially, gestational diabetes. CONCLUSIONS: Maternal obesity requires the development of effective interventions to improve pregnancy outcome. Strategies that incorporate a detailed understanding of the maternal metabolic environment and its consequences for the health of the mother and the growth of the child are likely to identify the best approach

Item Type:Articles
Keywords:ABNORMAL GLUCOSE-TOLERANCE ATHEROSCLEROSIS BIOLOGY BODY-MASS INDEX CARE clinical trials diabetes Diet ENGLAND ENVIRONMENT Epidemiology EXCESSIVE WEIGHT-GAIN FAT Gestational diabetes GESTATIONAL DIABETES-MELLITUS GLUCOSE growth HEALTH HEART IMPACT INCREASED RISK INFANT insulin Insulin resistance INSULIN-RESISTANCE INTERVENTION LOW-DENSITY-LIPOPROTEIN MASS Maternal obesity Metabolism MS NEONATAL BIRTH-WEIGHT Obesity OF-THE-LITERATURE outcome OUTCOMES PIMA INDIAN WOMEN PREGNANCY PREVENTION randomized controlled trials RANDOMIZED CONTROLLED-TRIAL RECREATIONAL PHYSICAL-ACTIVITY RESISTANCE RISK Ro Scotland Survey TRIAL trials TYPE-2 weight WOMEN
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Nelson, Professor Scott
Authors: Nelson, S. M., Matthews, P., and Poston, L.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities
Journal Name:Human Reproduction Update
ISSN:1355-4786

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