Stott, D.I., McLearie, J., and Neilson, L. (1986) Analysis of the clonal origins of autoantibodies against thyroglobulin and DNA in autoimmune thyroiditis and systemic lupus erythematosus. Clinical and Experimental Immunology, 65(3), pp. 520-533.
We have analysed the isoelectric focusing (IEF) spectra of antithyroglobulin autoantibodies in the sera of patients with autoimmune thyroiditis, and of anti-dsDNA autoantibodies in the sera of patients with systemic lupus erythematosus (SLE), NZB/NZW F1 hybrid, MRL-lpr/lpr and MRL/++ male and female mice. Ninety-two per cent of patients with anti-thyroglobulin autoantibodies had a polyclonal spectrotype compared with only 25% of SLE patients analysed for anti-dsDNA. Fifty-five per cent of the latter had monoclonal spectrotypes, the remainder being either biclonal or having a dominant clone on a polyclonal background. By contrast, only two out of 61 autoimmune thyroiditis patients expressed monoclonal anti-thyroglobulin autoantibodies. All of the lupus mice had highly restricted spectrotypes (monoclonal or biclonal) of anti-dsDNA autoantibodies. The implications of these results for the aetiology of autoimmunity are discussed.
|Glasgow Author(s) Enlighten ID:||Stott, Professor David|
|Authors:||Stott, D.I., McLearie, J., and Neilson, L.|
|Subjects:||Q Science > QR Microbiology > QR180 Immunology|
|College/School:||College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation|
|Journal Name:||Clinical and Experimental Immunology|
|Publisher:||Wiley-Blackwell Publishing Ltd.|