The presence of paraproteins in the sera of 10 patients with chronic lymphocytic leukaemia (CLL) was investigated using immunoisoelectric focusing. Monoclonal immunoglobulins were found in nine of these 10 sera. Five sera contained a single monoclonal IgM paraprotein, one serum contained a single monoclonal IgG paraprotein, while three sera contained more than one monoclonal paraprotein--namely, IgM + IgD, IgM + IgG, and IgM + IgD + IgG. The results indicate that the malignant B cells of CLL may be at a later stage of differentiation than previously assumed and serum monoclonal immunoglobulin could be of value as a tumour marker.
|Glasgow Author(s) Enlighten ID:||Stott, Professor David|
|Authors:||Sinclair, D., Dagg, J.H., Mowatt, A.M., Parrott, D.M., and Stott, D.I.|
|Subjects:||Q Science > QR Microbiology > QR180 Immunology|
|College/School:||College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation|
|Journal Name:||Journal of Clinical Pathology|
|Publisher:||BMJ Publishing Group Ltd.|