Marioni, R. E., Deary, I. J., Strachan, M. W., Lowe, G. D., Rumley, A., Murray, G. D. and Price, J. F. (2010) Blood rheology and cognition in the Edinburgh Type 2 Diabetes Study. Age and Ageing, 39(3), pp. 354-359. (doi: 10.1093/ageing/afq021)
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Abstract
Methods: a cross-sectional cohort of 1,066 men and women with type 2 diabetes (Edinburgh Type 2 Diabetes Study) was used for the analysis. Plasma viscosity and haematocrit were measured in venous blood samples at baseline. Contemporaneously, a battery of seven cognitive tests was administered to all participants. These data were used to derive a general intelligence factor, g. A vocabulary-based test was also administered as an estimate of prior intelligence, and adjustment for scores on this test was used to estimate lifetime cognitive decline. Results: increased plasma viscosity was associated with poorer age- and sex-adjusted scores on the cognitive domains of processing speed, mental flexibility and general intelligence, g, with standardised regression coefficients -0.092 (P < 0.01), -0.077 (P < 0.05) and -0.093 (P < 0.01), respectively. After adjusting for vocabulary, education level, cardiovascular dysfunction, duration of diabetes and glycaemic control, the associations remained significant for the measure of processing speed and g, with standardised regression coefficients -0.059 (P < 0.05) and -0.051 (P < 0.05). Increased haematocrit was significantly associated with better age- and sex-adjusted cognitive scores on the majority of the tests and with g. However, significant associations were not retained after adjustments for additional covariates. Conclusions: increased plasma viscosity is associated with decreased cognitive ability and increased estimated lifetime cognitive decline. The relationship between haematocrit and cognitive ability requires further study
| Item Type: | Articles |
|---|---|
| Keywords: | AGE ASSOCIATION ASSOCIATIONS BLOOD cardiovascular risk cognition COGNITIVE DECLINE Cohort DECLINE diabetes DISEASE DURATION DYSFUNCTION ENGLAND fibrinogen haematocrit haemostasis HEMATOCRIT hemostasis LEVEL MEN Mental PLASMA RHEOLOGY SCORE Scotland stroke TESTS Type 2 diabetes type 2 diabetes mellitus TYPE-2 VASCULAR DEMENTIA VISCOSITY WOMEN |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Rumley, Dr Ann and Lowe, Professor Gordon |
| Authors: | Marioni, R. E., Deary, I. J., Strachan, M. W., Lowe, G. D., Rumley, A., Murray, G. D., and Price, J. F. |
| College/School: | College of Medical Veterinary and Life Sciences |
| Journal Name: | Age and Ageing |
| Publisher: | Oxford University Press |
| ISSN: | 0002-0729 |
| ISSN (Online): | 1468-2834 |
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