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Detection and identification of serum monoclonal immunoglobulin by immunoisoelectric focusing. Limits of sensitivity and use during relapse of multiple myeloma

Sinclair, D., Kumararatne, D.S., and Stott, D.I. (1984) Detection and identification of serum monoclonal immunoglobulin by immunoisoelectric focusing. Limits of sensitivity and use during relapse of multiple myeloma. Journal of Clinical Pathology, 37 (3). pp. 255-262. ISSN 0021-9746

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Abstract

The limits of detection of four classes of monoclonal immunoglobulin and free light chain in serum by isoelectric focusing and immunoisoelectric focusing have been determined and the sensitivity of these techniques compared with that obtained using immunoelectrophoresis and zonal electrophoresis with immunofixation. Immunoisoelectric focusing was 10-40 times more sensitive than immunoelectrophoresis and could be used to detect concentrations of monoclonal immunoglobulin that were undetectable by zonal electrophoresis with immunofixation. The relevance of this work in monitoring multiple myeloma during treatment and relapse is discussed.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s):Stott, Prof David
Authors: Sinclair, D., Kumararatne, D.S., and Stott, D.I.
Subjects:Q Science > QR Microbiology > QR180 Immunology
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Clinical Pathology
Publisher:BMJ Publishing Group Ltd.
ISSN:0021-9746

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