Disease-associated functions of IL-33: the new kid in the IL-1 family

Liew, F. Y., Pitman, N. I. and McInnes, I. B. (2010) Disease-associated functions of IL-33: the new kid in the IL-1 family. Nature Reviews Immunology, 10(2), pp. 103-110. (doi:10.1038/nri2692) (PMID:20081870)

Liew, F. Y., Pitman, N. I. and McInnes, I. B. (2010) Disease-associated functions of IL-33: the new kid in the IL-1 family. Nature Reviews Immunology, 10(2), pp. 103-110. (doi:10.1038/nri2692) (PMID:20081870)

Full text not currently available from Enlighten.

Abstract

Interleukin-33 (IL-33), a newly described member of the IL-1 family, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The IL-33 receptor, consisting of ST2 and IL-1 receptor accessory protein, is also widely expressed, particularly by T helper 2 (T<sub>H</sub>2) cells and mast cells. IL-33 is host-protective against helminth infection and reduces atherosclerosis by promoting T<sub>H</sub>2-type immune responses. However, IL-33 can also promote the pathogenesis of asthma by expanding T<sub>H</sub>2 cells and mediate joint inflammation, atopic dermatitis and anaphylaxis by mast cell activation. Thus IL-33 could be a new target for therapeutic intervention across a range of diseases.

Item Type:Articles
Keywords:AIRWAY INFLAMMATION HUMAN MAST-CELLS IL-1-LIKE CYTOKINE IL-33 IN-VIVO INTERLEUKIN-1 RECEPTOR MYOCARDIAL-INFARCTION RECEPTOR ACCESSORY PROTEIN ST2 GENE-PRODUCT SUBARACHNOID HEMORRHAGE TH2 CELLS
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McInnes, Professor Iain and Liew, Professor Foo and Pitman, Dr Nick
Authors: Liew, F. Y., Pitman, N. I., and McInnes, I. B.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Nature Reviews Immunology
Publisher:Nature Publishing Group
ISSN:1474-1733
ISSN (Online):1474-1741
Published Online:18 January 2010

University Staff: Request a correction | Enlighten Editors: Update this record

Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
486461The role of IL-35 in infection and inflammationFoo LiewMedical Research Council (MRC)G0801198Infection Immunity and Inflammation Medicine
445191The role of the 1L-33 in the innate and adaptive immune responses in asthmaGrace MurphyMedical Research Council (MRC)G0601422III -IMMUNOLOGY