Prospective study of matrix metalloproteinase-9 and risk of myocardial infarction and stroke in older men and women

Jefferis, B. J. et al. (2010) Prospective study of matrix metalloproteinase-9 and risk of myocardial infarction and stroke in older men and women. Atherosclerosis, 208(2), pp. 557-563. (doi: 10.1016/j.atherosclerosis.2009.08.018)

Abstract

Objectives: The endopeptidase matrix metalloproteinase-9 (MMP-9) is implicated in atherosclerotic plaque rupture. We investigate prospective associations between MMP-9 and MI or stroke in an older general population cohort, accounting for established and novel cardiovascular risk factors. Methods: Baseline serum MMP-9 was measured in incident MI (n = 368) and stroke (n = 299) cases and two controls per case, 'nested' in prospective studies of 4252 men and 4286 women aged 60-79 years, sampled from General Practices in Britain in 1998-2000, with 7-year follow-up for fatal and non-fatal MI and stroke. Results: Geometric mean MMP-9 was 528 ng/mL (IQR 397, 743) in MI cases compared to 501 ng/mL (IQR 370, 743) in controls, p = 0.10. Participants in the top compared to bottom third of MMP-9 levels had an age-adjusted odds ratio for MI of 1.53 (95% CI 1.09, 2.13), which attenuated to 1.18 (95% CI 0.81, 1.70) after adjustment for established and novel cardiovascular risk factors. There was weak evidence that OR differed according to pre-existing CVD; the OR for MI in 187 participants with pre-existing CVD was 2.20 (1.04, 4.64) and 1.24 (0.84, 1.82) in 715 participants without (LR test for interaction p = 0.06). Geometric mean MMP-9 levels were higher in stroke cases than controls; 522 ng/mL (IQR 363, 673) vs 487 (IQR 393, 704), p = 0.045; however adjustments similarly attenuated the associations. Conclusions: While serum MMP-9 is univariately associated with risk of MI and stroke, it is not a strong independent risk marker for either. (C) 2009 Elsevier Ireland Ltd. All rights reserved

• Item Type: Articles
• Keywords: ASSOCIATION cardiovascular risk CARDIOVASCULAR-DISEASE Cohort CORONARY-ARTERY-DISEASE DISEASE Epidemiology FOLLOW-UP HEART-DISEASE inflammation LEVEL MATRIX METALLOPROTEINASES MMP-9 Myocardial infarction MYOCARDIAL-INFARCTION PLASMA MATRIX-METALLOPROTEINASE-9 Prospective RISK risk factors RISK-FACTOR RISK-FACTORS SERUM MATRIX-METALLOPROTEINASE-9 stroke SUSCEPTIBILITY WOMEN
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Rumley, Dr Ann and Lowe, Professor Gordon and Welsh, Professor Paul
• Authors: Jefferis, B. J., Whincup, P., Welsh, P., Wannamethee, G., Rumley, A., Lennon, L., Thomson, A., Lawlor, D., Carson, C., Ebrahim, S., and Lowe, G.
• College/School: College of Medical Veterinary and Life Sciences
• Journal Name: Atherosclerosis
• ISSN: 0021-9150