Secondhand smoke (SHS) exposure is associated with circulating markers of inflammation and endothelial function in adult men and women

Jefferis, B. J. et al. (2010) Secondhand smoke (SHS) exposure is associated with circulating markers of inflammation and endothelial function in adult men and women. Atherosclerosis, 208(2), pp. 550-556. (doi: 10.1016/j.atherosclerosis.2009.07.044)

Abstract

Aims: Secondhand smoke (SHS) exposure is associated with elevated CHD risks. Yet the pathways through which this may operate have not been investigated in epidemiologic studies with objective SHS exposure measures and a wide range of CHD risk factors associated with active smoking. Therefore we investigate associations between SHS exposure and CHD risk factors, to clarify how SHS exposure may raise risk of CHD. Methods: Cross-sectional population-based study of 5029 men and women aged 59-80 years from primary care practices in Great Britain. Smoking, behavioural and demographic information was reported in questionnaires; nurses made physical measurements and took blood samples for analysis of serum cotinine and markers of inflammation, hemostasis and endothelial dysfunction. Results: Active cigarette smokers had lower albumin and higher triglycerides, CRP, IL-6, white cell count, fibrinogen, blood viscosity, factor VIII, VWF and t-PA than non-smokers. Among non-smokers, serum cotinine levels were independently positively associated with CRP, fibrinogen, factor VIII, VWF and t-PA and inversely associated with albumin, after adjustment for age, gender, social and behavioural factors. The differences in CRP, fibrinogen and albumin between cotinine <= 0.05 and >0.7 ng/ml were one-third to one half the size of differences between cotinine <= 0.05 ng/ml and current smokers, but were of similar magnitude for VWF and t-PA. Conclusions: Endothelial, inflammatory and haemostatic markers related to CHD risk showed independent associations with SHS exposure in the same direction as those for active smoking. Results aid understanding of the associations between SHS exposure and elevated CHD risks. (C) 2009 Elsevier Ireland Ltd. All rights reserved

• Item Type: Articles
• Keywords: AGE ASSOCIATION C-REACTIVE PROTEIN CARDIOVASCULAR-DISEASE CIGARETTE-SMOKING CORONARY-HEART-DISEASE COTININE CVD risk factors diabetes DISEASE ENDOTHELIAL FUNCTION ENVIRONMENTAL TOBACCO-SMOKE Epidemiology inflammation PASSIVE SMOKING PATHWAY RISK risk factors RISK-FACTOR RISK-FACTORS Secondhand smoke stroke TISSUE-PLASMINOGEN ACTIVATOR WOMEN YOUNG-ADULTS
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Rumley, Dr Ann and Lowe, Professor Gordon and Welsh, Professor Paul
• Authors: Jefferis, B. J., Lowe, G. D. O., Welsh, P., Rumley, A., Lawlor, D. A., Ebrahim, S., Carson, C., Doig, M., Feyerabend, C., McMeekin, L., Wannamethee, S. G., Cook, D. G., and Whincup, P. H.
• College/School: College of Medical Veterinary and Life Sciences
• Journal Name: Atherosclerosis
• ISSN: 0021-9150