Huda, S. S., Brodie, L.E. and Sattar, N. (2010) Obesity in pregnancy: prevalence and metabolic consequences. Seminars in Fetal and Neonatal Medicine, 15(2), pp. 70-76. (doi: 10.1016/j.siny.2009.09.006)
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Abstract
Rates of obesity have increased exponentially worldwide to almost epidemic proportions. This is associated with a marked increase in adverse maternal and perinatal outcomes and subsequent burden on health care resources. In particular, maternal obesity is linked to numerous metabolic complications including subfertility, gestational diabetes, hypertensive disorders of pregnancy and thromboembolism with potential long-term health consequences for both mother and child. The underlying pathophysiology linking maternal obesity and adverse outcomes is complex but is likely to involve alterations in glucose and lipid metabolism, inflammation, perturbances in adipokines and vascular dysfunction all seen in obese women. Intervention studies are underway to determine whether alteration of maternal lifestyle can improve maternal and fetal outcomes.
| Item Type: | Articles |
|---|---|
| Keywords: | Adipokines ADIPOSE-TISSUE BODY-MASS INDEX CANCER CARE diabetes DYSFUNCTION ENGLAND Epidemiology EXCESSIVE WEIGHT-GAIN Free fatty acids Gestational diabetes GESTATIONAL DIABETES-MELLITUS GLUCOSE haemostasis HEALTH INCREASE inflammation Insulin resistance INSULIN-RESISTANCE INTERVENTION LIFE LONG-TERM LONGITUDINAL CHANGES MASS Maternal obesity MOTHERS NEURAL-TUBE DEFECTS Obesity outcome OUTCOMES PREGNANCY PREVALENCE RANDOMIZED CONTROLLED-TRIAL Scotland THROMBOEMBOLISM VISCERAL FAT weight WOMEN |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Sattar, Professor Naveed and Huda, Dr Shahzya |
| Authors: | Huda, S. S., Brodie, L.E., and Sattar, N. |
| College/School: | College of Medical Veterinary and Life Sciences College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Seminars in Fetal and Neonatal Medicine |
| ISSN: | 1744-165X |
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