The therapeutic potential of the filarial nematode-derived immunodulator, ES-62 in inflammatory disease

Harnett, M. M. , Melendez, A. J. and Harnett, W. (2010) The therapeutic potential of the filarial nematode-derived immunodulator, ES-62 in inflammatory disease. Clinical and Experimental Immunology, 159(3), pp. 256-267. (doi:10.1111/j.1365-2249.2009.04064.x)

Harnett, M. M. , Melendez, A. J. and Harnett, W. (2010) The therapeutic potential of the filarial nematode-derived immunodulator, ES-62 in inflammatory disease. Clinical and Experimental Immunology, 159(3), pp. 256-267. (doi:10.1111/j.1365-2249.2009.04064.x)

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Publisher's URL: http://dx.doi.org/10.1111/j.1365-2249.2009.04064.x

Abstract

The dramatic recent rise in the incidence of allergic or autoimmune inflammatory diseases in the West has been proposed to reflect the lack of appropriate priming of the immune response by infectious agents such as parasitic worms during childhood. Consistent with this, there is increasing evidence supporting an inverse relationship between worm infection and T helper type 1/17 (Th1/17)-based inflammatory disorders such as rheumatoid arthritis, inflammatory bowel disease, type 1 diabetes and multiple sclerosis. Perhaps more surprisingly, given that such worms often induce strong Th2-type immune responses, there also appears to be an inverse correlation between parasite load and atopy. These findings therefore suggest that the co-evolution of helminths with hosts, which has resulted in the ability of worms to modulate inflammatory responses to promote parasite survival, has also produced the benefit of protecting the host from pathological lesions arising from aggressive proinflammatory responses to infection or, indeed, aberrant inflammatory responses underlying autoimmune and allergic disorders. By focusing upon the properties of the filarial nematode-derived immunomodulatory molecule, ES-62, in this review we shall discuss the potential of exploiting the immunomodulatory products of parasitic worms to identify and develop novel therapeutics for inflammation

Item Type:Articles
Keywords:AIRWAY INFLAMMATION allergy autoimmune disease CONTAINING SECRETED PRODUCT DENDRITIC CELLS diabetes ES-62 HELMINTH INFECTION immunomodulation INFECTION inflammation LYMPHATIC FILARIASIS nematodes PROTEIN TRANSDUCTION REGULATORY T-CELLS RHEUMATOID-ARTHRITIS SCAVENGER RECEPTOR CD163 SURVIVAL SYSTEMIC-LUPUS-ERYTHEMATOSUS
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Harnett, Professor Margaret and Melendez Romero, Dr Alirio
Authors: Harnett, M. M., Melendez, A. J., and Harnett, W.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Clinical and Experimental Immunology
Publisher:Wiley-Blackwell Publishing Ltd.
ISSN:0009-9104
ISSN (Online):1365-2249
Published Online:01 December 2009
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
462311Therapeutic potential of Sphingosine Kinase blockage in allergic anaphylaxis.Alirio Melendez RomeroMedical Research Council (MRC)G0700794Institute of Infection Immunity and Inflammation