Nitrones for understanding and ameliorating the oxidative stress associated with aging

El Fangour, S., Marini, M., Good, J., McQuaker, S.J., Shiels, P.G. and Hartley, R.C. (2009) Nitrones for understanding and ameliorating the oxidative stress associated with aging. Age, 31(4), pp. 269-276. (doi:10.1007/s11357-009-9098-z) (PMID:19479343) (PMCID:PMC2813050)

El Fangour, S., Marini, M., Good, J., McQuaker, S.J., Shiels, P.G. and Hartley, R.C. (2009) Nitrones for understanding and ameliorating the oxidative stress associated with aging. Age, 31(4), pp. 269-276. (doi:10.1007/s11357-009-9098-z) (PMID:19479343) (PMCID:PMC2813050)

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Abstract

Oxidative damage from reactive oxygen species (ROS) and the carbon-centred radicals arising from them is important to the process of aging, and age-related diseases are generally caused, exacerbated or mediated by oxidative stress. Nitrones can act as spin traps to detect, identify, quantify and locate the radicals responsible using electron paramagnetic resonance (EPR or ESR) spectroscopy, and a new carnitine-derived nitrone, CarnDOD-7C, designed to accumulate in mitochondria is reported. Nitrones also have potential as therapeutic antioxidants, e.g. for slowing cellular aging, and as tools for chemical biology. Two low-molecular weight nitrones, DIPEGN-2 and DIPEGN-3, are reported, which combine high water-solubility with high lipophilicity and obey Lipinski's rule of five.

Item Type:Articles
Keywords:Aging, Antioxidants, Biology, Depmpo spin trap, Disease, Electron paramagnetic resonance spectroscopy, Fluorescent, L-carnitine, Mitochondria, Nitrones, Oxidative stress, Probes, Prospects, Radicals, Reactive oxygen species, Superoxide
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Good, Mr James and Hartley, Professor Richard and Shiels, Professor Paul
Authors: El Fangour, S., Marini, M., Good, J., McQuaker, S.J., Shiels, P.G., and Hartley, R.C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
College of Science and Engineering > School of Chemistry
Journal Name:Age
Publisher:Springer Netherlands
ISSN:0161-9152
ISSN (Online):1574-4647
Published Online:29 May 2009

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