Identifying the Cells Breaching Self-Tolerance in Autoimmunity

Benson, R.A., Patakas, A., Conigliaro, P., Rush, C. M., Garside, P. , McInnes, I. B. and Brewer, J. M. (2010) Identifying the Cells Breaching Self-Tolerance in Autoimmunity. Journal of Immunology, 184(11), pp. 6378-6385. (doi:10.4049/jimmunol.0903951) (PMID:20421640)

Benson, R.A., Patakas, A., Conigliaro, P., Rush, C. M., Garside, P. , McInnes, I. B. and Brewer, J. M. (2010) Identifying the Cells Breaching Self-Tolerance in Autoimmunity. Journal of Immunology, 184(11), pp. 6378-6385. (doi:10.4049/jimmunol.0903951) (PMID:20421640)

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Publisher's URL: http://www.jimmunol.org

Abstract

Activation of auto-reactive T cells by activated dendritic cells (DCs) presenting self-Ag is widely assumed to be the precipitating event in the development of autoimmune disease. However, despite such widely held preconceptions, supporting data are scarce and subjective, particularly in experimental arthropathy. We have adapted a novel murine model of breach of self-tolerance allowing evaluation of the contribution of endogenous DCs to the development of autoimmune responses and disease. For the first time, we reveal the critical role played by conventional DCs, and the timing and location of this process. We further demonstrate the importance of this finding by clinically relevant, therapeutic manipulation of conventional DC function, resulting in decreased autoimmune phenotype and disease severity. The Journal of Immunology, 2010, 184: 6378-6385

Item Type:Articles
Keywords:ACTIVATION ANTIGEN autoimmune disease CELLS COLLAGEN-INDUCED ARTHRITIS DENDRITIC CELLS Development DISEASE EPSTEIN-BARR-VIRUS immunity IN-VIVO DEPLETION INDUCTION inflammation JOINT MODEL PHENOTYPE PLASMACYTOID DENDRITIC CELLS RESPONSES RHEUMATOID-ARTHRITIS Scotland SEVERITY T cells T-cell T-CELLS TNF-ALPHA
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McInnes, Professor Iain and Conigliaro, Dr Paola and Rush, Dr Catherine and Brewer, Professor James and Garside, Professor Paul and Benson, Dr Robert
Authors: Benson, R.A., Patakas, A., Conigliaro, P., Rush, C. M., Garside, P., McInnes, I. B., and Brewer, J. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Immunology
Journal Abbr.:J. Immunol.
ISSN:0022-1767
ISSN (Online):1550-6606
Published Online:26 April 2010

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