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IgM-producing tumors in the BALB/c mouse: a model for B-cell maturation

Andersson, J., Buxbaum, J., Citronbaum, R., Douglas, S., Forni, L., Melchers, F., Pernis, B., and Stott, D.I. (1974) IgM-producing tumors in the BALB/c mouse: a model for B-cell maturation. Journal of Experimental Medicine, 140 (3). pp. 742-763. ISSN 0022-1007

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Publisher's URL: http://www.jem.org/content/vol140/issue3/index.shtml

Abstract

Five adjuvant induced BALB/c tumors producing IgM—McPc 1748, W 3469, TEPC 183, McPc 774, and Y 5781—were characterized morphologically by electron microscopy, analysis of the distribution of surface-bound and intracytoplasmic IgM using immunofluorescence, and by biochemical study of IgM synthesis, turnover, and secretion. The cells of different tumors appear to represent different stages in B-cell maturation when compared to normal, lipopolysaccharide-stimulated B cells. Thus, McPc 1748 tumor cells resemble 10–25-h stimulated normal B cells, 3469 cells resemble 20–35-h stimulated B cells, TEPC 183 cells resemble 45–65-h stimulated B cells, Y 5781 cells resemble 80–110-h stimulated B cells, and McPc 774 cells resemble 100–130-h stimulated B cells.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Stott, Prof David
Authors: Andersson, J., Buxbaum, J., Citronbaum, R., Douglas, S., Forni, L., Melchers, F., Pernis, B., and Stott, D.I.
Subjects:Q Science > QA Mathematics > QA75 Electronic computers. Computer science
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Experimental Medicine
Publisher:Rockefeller University Press
ISSN:0022-1007
Copyright Holders:Copyright © 1974 Rockefeller University Press
First Published:First published in The Journal of Experimental Medicine 140: 742-763
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher.

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