microRNAs: a role in drug resistance in parasitic nematodes?

Devaney, E.A. , Winter, A.D. and Britton, C. (2010) microRNAs: a role in drug resistance in parasitic nematodes? Trends in Parasitology, 26(9), pp. 428-433. (doi:10.1016/j.pt.2010.05.003)

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Abstract

Drug resistance in parasitic nematodes is an increasing problem worldwide, with resistance reported to all three commonly used classes of anthelmintics. Most studies to date have sought to correlate the resistant phenotype with genotypic changes in putative target molecules. Although this approach has identified mutations in several relevant genes, resistance might result from a complex interaction of different factors. Here we propose an alternative mechanism underlying the development of drug resistance based on functional differences in microRNA activity in resistant parasites. microRNAs play an important role in resistance to chemotherapeutic agents in many tumour cells and here we discuss whether they might also be involved in anthelmintic resistance in parasitic nematodes

Item Type:Articles
Keywords:Anthelmintics development Mutation parasitology Phenotype veterinary Veterinary Medicine
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Devaney, Professor Eileen and Britton, Dr Collette
Authors: Devaney, E.A., Winter, A.D., and Britton, C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Trends in Parasitology
Publisher:Elsevier Ltd
ISSN:1471-4922

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
441591A comparative analysis of Hsp90 its possible role in drug resistance in nematode parasitesEileen DevaneyBiotechnology and Biological Sciences Research Council (BBSRC)BB/E013473/1III - PARASITOLOGY