Potent lentiviral restriction by a synthetic feline TRIM5 cyclophilin A fusion

Dietrich, I., MacIntyre, A., McMonagle, E., Price, A.J., James, L.C., McEwan, W.A., Hosie, M.J. and Willett, B.J. (2010) Potent lentiviral restriction by a synthetic feline TRIM5 cyclophilin A fusion. Journal of Virology, 84(17), pp. 8980-8985. (doi: 10.1128/JVI.00858-10)

Full text not currently available from Enlighten.

Abstract

A synthetic feline TRIM5-cyclophilin A fusion protein (feTRIMCyp) was generated and transduced into feline cells. feTRIMCyp was highly efficient at preventing infection with human (HIV) and feline (FIV) immunodeficiency virus pseudotypes, and feTRIMCyp-expressing cells resisted productive infection with either FIV-Fca or FIV-Pco. The restriction of FIV infection by feTRIMCyp was reversed by the cyclosporine (Cs) derivatives NIM811 and Debio-025 but less so by Cs itself. FeTRIMCyp and FIV infections of the cat offer a unique opportunity to evaluate TRIMCyp-based approaches to genetic therapy for HIV infection and the treatment of AIDS

Item Type:Articles
Keywords:Derivatives, research, therapy, veterinary, veterinary Medicine
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hosie, Professor Margaret and Willett, Professor Brian and McMonagle, Mrs Linda and Dietrich, Dr Isabelle
Authors: Dietrich, I., MacIntyre, A., McMonagle, E., Price, A.J., James, L.C., McEwan, W.A., Hosie, M.J., and Willett, B.J.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
Journal Name:Journal of Virology
Journal Abbr.:J. Virol.
ISSN:0022-538X
ISSN (Online):1098-5514
Published Online:16 June 2010

University Staff: Request a correction | Enlighten Editors: Update this record