Suppression of adaptive immunity to heterologous antigens during Plasmodium infection through hemozoin-induced failure of dendritic cell function

Millington, O.R., Di Lorenzo, C., Phillips, R., Garside, P. and Brewer, J.M. (2006) Suppression of adaptive immunity to heterologous antigens during Plasmodium infection through hemozoin-induced failure of dendritic cell function. Journal of Biology, 5(2), pp. 1-22. (doi:dx.doi.org/10.1186/jbiol34)

Millington, O.R., Di Lorenzo, C., Phillips, R., Garside, P. and Brewer, J.M. (2006) Suppression of adaptive immunity to heterologous antigens during Plasmodium infection through hemozoin-induced failure of dendritic cell function. Journal of Biology, 5(2), pp. 1-22. (doi:dx.doi.org/10.1186/jbiol34)

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Abstract

Dendritic cells (DCs) are central to the initiation and regulation of the adaptive immune response during infection. Modulation of DC function may therefore allow evasion of the immune system by pathogens. Significant depression of the host's systemic immune response to both concurrent infections and heterologous vaccines has been observed during malaria infection, but the mechanisms underlying this immune hyporesponsiveness are controversial.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Di Lorenzo, Miss Caterina and Millington, Dr Owain and Brewer, Professor James and Garside, Professor Paul
Authors: Millington, O.R., Di Lorenzo, C., Phillips, R., Garside, P., and Brewer, J.M.
Subjects:Q Science > QR Microbiology > QR180 Immunology
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Biology

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