Expression and function of T cell homing molecules in Hodgkin's lymphoma

Machado, L. et al. (2009) Expression and function of T cell homing molecules in Hodgkin's lymphoma. Cancer Immunology Immunotherapy, 58(1), pp. 85-94. (doi:10.1007/s00262-008-0528-z [Machado, Lee; Morgan, Susan; Murray, Paul; Hunter, Beatrix; Hamilton, Emma; Thomas, Wendy; Steven, Neil; Chapman, Ann; Lee, Steven P.] Univ Birmingham, Canc Res UK Inst Canc Studies, Birmingham B15 2TT, W Midlands, England. [Jar)

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Abstract

Circulating T lymphocytes enter a tissue if they express appropriate chemokine receptors and adhesion molecules to engage ligands presented at this site. To aid rational development of T cell-based therapies for Hodgkin's lymphoma (HL), we have assessed the expression and function of homing receptors on tumour-infiltrating T cells in HL and compared them with T cells from unaffected lymph nodes and colorectal cancer tissue. Chemokine receptors CXCR3, CXCR4 and CCR7 were expressed on a large proportion of T cells within HL tissue and mediated chemotaxis to purified chemokine. The corresponding ligands (CXCL10, CXCL12, CCL21) were expressed on the malignant cells and/or vascular endothelium. Adhesion molecules including CD62L were widely expressed on HL-derived T cells and their corresponding ligands were detected on vessels within the tumour. This homing phenotype was distinct from T cells isolated from colorectal cancer, but matched closely the phenotype of T cells from unaffected lymph nodes. Thus, T cell recruitment to HL resembles entry of naive/central memory T cells into normal lymph nodes. This has important implications for current approaches to treat HL using T cells activated and expanded in vitro that lack CCR7 and CD62L expression

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Jarrett, Professor Ruth and Lee, Ms Sylvia
Authors: Machado, L., Jarrett, R., Morgan, S., Murray, P., Hunter, B., Hamilton, E., Crocker, J., Thomas, W., Steven, N., Ismail, T., Chapman, A., Adams, D.H., and Lee, S.P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Cancer Immunology Immunotherapy
ISSN:0340-7004

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