Isolation of an Infectious Endogenous Retrovirus in a Proportion of Live Attenuated Vaccines for Pets

Miyazawa, T., Yoshikawa, R., Golder, M., Okada, M., Stewart, H. and Palmarini, M. (2010) Isolation of an Infectious Endogenous Retrovirus in a Proportion of Live Attenuated Vaccines for Pets. Journal of Virology, 84(7), pp. 3690-3694. (doi:10.1128/JVI.02715-09)

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Abstract

The genomes of all animal species are colonized by endogenous retroviruses (ERVs). Although most ERVs have accumulated defects that render them incapable of replication, fully infectious ERVs have been identified in various mammals. In this study, we isolated a feline infectious ERV (RD-114) in a proportion of live attenuated vaccines for pets. Isolation of RD-114 was made in two independent laboratories using different detection strategies and using vaccines for both cats and dogs commercially available in Japan or the United Kingdom. This study shows that the methods currently employed to screen veterinary vaccines for retroviruses should be reevaluated

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Stewart, Ms Hazel and Palmarini, Professor Massimo and Golder, Mr Matthew
Authors: Miyazawa, T., Yoshikawa, R., Golder, M., Okada, M., Stewart, H., and Palmarini, M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Virology
ISSN:0022-538X

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