Variations in serum concentration of phenobarbitone in dogs receiving regular twice daily doses in relation to the times of administration

Monteiro, R., Anderson, T.J. , Innocent, G., Evans, N.P. and Penderis, J. (2009) Variations in serum concentration of phenobarbitone in dogs receiving regular twice daily doses in relation to the times of administration. Veterinary Record, 165(19), pp. 556-558. (doi:10.1136/vr.165.19.556)

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Publisher's URL: http://dx.doi.org/10.1136/vr.165.19.556

Abstract

The laboratory records of 1427 client-owned dogs on chronic phenobarbitone treatment were analysed. They were divided into two groups: the 918 dogs from which blood samples were collected at the trough, that is, within two hours before the next dose of phenobarbitone, and the 509 dogs from which samples were taken during the non-trough period. There were no significant differences between the mean serum concentrations of phenobarbitone in the trough and non-trough samples from dogs receiving doses ranging from 2 mg/kg per day to more than 10 mg/kg per day. However, the higher doses of phenobarbitone were associated with progressively lower phenobarbitone concentrations in the trough group relative to the non-trough group, and this difference was significant at doses of more than 10 mg/kg per day

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Anderson, Professor Jim and Penderis, Professor Jacques and Evans, Professor Neil
Authors: Monteiro, R., Anderson, T.J., Innocent, G., Evans, N.P., and Penderis, J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
Journal Name:Veterinary Record
Publisher:B M J Group
ISSN:0042-4900
ISSN (Online):2042-7670

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