Progression to detrusor-muscle invasion in bladder carcinoma is associated with polysomy of chromosomes 1 and 8 in recurrent pTa/pT1 tumours

Watters, A.D., Going, J.J., Grigor, K.M. and Bartlett, J.M.S. (2002) Progression to detrusor-muscle invasion in bladder carcinoma is associated with polysomy of chromosomes 1 and 8 in recurrent pTa/pT1 tumours. European Journal of Cancer, 38(12), pp. 1593-1599. (doi: 10.1016/S0959-8049(02)00082-5)

Abstract

Transitional cell carcinoma (TCC) provides a unique model of cancer recurrence and progression. Sequential tumours (n = 100) from 57 patients with an index pTa or pT1 TCC were studied using fluorescence in situ hybridisation (FISH), to determine aberrations of chromosomes 1 and 8. Thirty-seven patients experienced recurrences; eleven developed muscle invasive tumours (pT2+). Polysomy of chromosomes I or 8 was associated with pT1 TCC (P = 0.0017 and P = 0.0037, respectively), but not with recurrence. Progression was associated with polysomy of chromosomes I (P = 0.003) and 8 (P = 0.011) in pTa/pT1 recurrences, but not with stage. In conclusion, patients who subsequently developed invasive TCC (pT2+) had significantly higher rates of ancusomy (90%) in their superficial cancers than those patients who did not progress (P = 0.009). Investigation of sequential tumours in patients with recurrent and progressive TCC showed that polysomy of chromosomes I and 8 were linked to subsequent detrusor muscle invasion, but not recurrence per se.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Going, Dr James
• Authors: Watters, A.D., Going, J.J., Grigor, K.M., and Bartlett, J.M.S.
• Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer); R Medicine > RB Pathology
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: European Journal of Cancer
• ISSN: 0959-8049