Basement membranes and human disease

Van Agtmael, T. and Bruckner-Tuderman, L. (2010) Basement membranes and human disease. Cell and Tissue Research, 339(1), pp. 167-188. (doi: 10.1007/s00441-009-0866-y)

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Publisher's URL: http://dx.doi.org/10.1007/s00441-009-0866-y

Abstract

In 1990 the role of basement membranes in human disease was established by the identification of COL4A5 mutations in Alport’s syndrome. Since then the number of diseases caused by mutations in basement membrane components has steadily increased as has our understanding of the roles of basement membranes in organ development and function. However, many questions remain as to the molecular and cellular consequences of these mutations and how they lead to the observed disease phenotypes. Despite this, exciting progress has recently been made with potential treatment options for some of these so far incurable diseases.

Item Type:Articles
Additional Information:The original publication is available at www.springerlink.com
Keywords:Basement membrane, laminin, collagen, nidogen
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Van Agtmael, Dr Tom
Authors: Van Agtmael, T., and Bruckner-Tuderman, L.
Subjects:Q Science > QH Natural history > QH301 Biology
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Cell and Tissue Research
Publisher:Springer
ISSN:0302-766X
ISSN (Online):1432-0878
Published Online:15 September 2009
Copyright Holders:Copyright © 2010 Springer
First Published:First published in Cell and Tissue Research 339(1):167-188
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
471511Collagen type IV in vascular biologyTom Van AgtmaelMedical Research Council (MRC)G0601268Institute of Cardiovascular and Medical Sciences