Basement membranes and human disease

Van Agtmael, T. and Bruckner-Tuderman, L. (2010) Basement membranes and human disease. Cell and Tissue Research, 339(1), pp. 167-188. (doi: 10.1007/s00441-009-0866-y)

Abstract

In 1990 the role of basement membranes in human disease was established by the identification of COL4A5 mutations in Alport’s syndrome. Since then the number of diseases caused by mutations in basement membrane components has steadily increased as has our understanding of the roles of basement membranes in organ development and function. However, many questions remain as to the molecular and cellular consequences of these mutations and how they lead to the observed disease phenotypes. Despite this, exciting progress has recently been made with potential treatment options for some of these so far incurable diseases.

• Item Type: Articles
• Additional Information: The original publication is available at www.springerlink.com
• Keywords: Basement membrane, laminin, collagen, nidogen
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Van Agtmael, Professor Tom
• Authors: Van Agtmael, T., and Bruckner-Tuderman, L.
• Subjects: Q Science > QH Natural history > QH301 Biology
• College/School: College of Medical Veterinary and Life Sciences; College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Cell and Tissue Research
• Publisher: Springer
• ISSN: 0302-766X
• ISSN (Online): 1432-0878
• Published Online: 15 September 2009
• Copyright Holders: Copyright © 2010 Springer
• First Published: First published in Cell and Tissue Research 339(1):167-188
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher

Related URLs

• PubMed

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
47151	1	Collagen type IV in vascular biology	Tom Van Agtmael	Medical Research Council (MRC)	G0601268	Institute of Cardiovascular and Medical Sciences