Stear, M. J., Boag, B., Cattadori, I. and Murphy, L. (2009) Genetic variation in resistance to mixed, predominantly Teladorsagia circumcincta nematode infections of sheep: from heritabilities to gene identification. Parasite Immunology, 31(5), pp. 274-282. (doi: 10.1111/j.1365-3024.2009.01105.x)
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Abstract
In cool temperate areas, such as Scotland, sheep are infected by a variety of nematodes but the dominant nematode is Teladorsagia circumcincta. Resistant animals have one or more of the following features: fewer adult nematodes, more inhibited larvae, shorter adult nematodes and decreased production of nematode eggs. In lambs at the end of the first grazing season, the heritability of adult worm length is very strong, whereas the heritability of egg production is moderate. The heritability of worm number is low while there is no detectable genetic variation in the number of inhibited larvae. The major mechanisms underlying resistance to T. circumcincta appear to be the IgA mediated suppression of worm growth and the mast cell mediated regulation of worm number. Mast cell responses are slow to develop, possibly because they are responsible for protein loss and reduced growth of the host. Two genes have been repeatedly associated with resistance to T. Circumcincta: the MHC class II DRB1 locus on chromosome 20 and the interferon-gamma locus on chromosome 3. Although the causative mutations are still unknown both genes are plausible candidates.
| Item Type: | Articles |
|---|---|
| Keywords: | Adult, animals, female, genetic predisposition to disease, genetic variation, genetics, HLA-DR antigens, host-parasite interactions, immunology, interferon-gamma, mutation, nematode infections, parasite egg count, parasitology, pathogenicity, Scotland, sheep, sheep diseases, trichostrongyloidea, trichostrongyloidiasis, veterinary |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Cattadori, Dr Isabella and Stear, Professor Mike and Murphy, Dr Lisa |
| Authors: | Stear, M. J., Boag, B., Cattadori, I., and Murphy, L. |
| Subjects: | S Agriculture > SF Animal culture > SF600 Veterinary Medicine |
| College/School: | College of Medical Veterinary and Life Sciences College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Parasite Immunology |
| Journal Abbr.: | Parasite immunol. |
| Publisher: | Wiley-Blackwell Publishing Ltd. |
| ISSN: | 0141-9838 |
| ISSN (Online): | 1365-3024 |
| Published Online: | 12 February 2009 |
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