Yuan, Z.Q., Bennett, l., Campo, S. and Nasir, L. (2010) Bovine papillomavirus type 1 E2 and E7 proteins down-regulate Toll Like Receptor 4 (TLR4) expression in equine fibroblasts. Virus Research, 149(1), pp. 124-127. (doi: 10.1016/j.virusres.2010.01.008)
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Abstract
BPV-1 and less commonly BPV-2 are associated with the pathogenesis of equine skin tumours termed sarcoids. We recently documented the transcriptional changes that are induced by BPV-1 in equine fibroblasts using microarray analyses. TLR4 expression was found to be significantly down-regulated by BPV-1. In the present study, we show that TLR4 expression is significantly decreased following the exogenous expression of BPV-1 E2 and E7 in primary equine fibroblasts. The results were confirmed by the demonstration of increased TLR4 expression following siRNA suppression of BPV-1 E2 and E7 viral gene expression. These data imply that BPV-1 is able to subvert the innate immune response by downregulation of TLR4.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Campo, Professor Saveria and Nasir, Professor Lubna and Yuan, Dr Zhengqiang |
| Authors: | Yuan, Z.Q., Bennett, l., Campo, S., and Nasir, L. |
| Subjects: | Q Science > QR Microbiology > QR355 Virology |
| College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Journal Name: | Virus Research |
| Publisher: | Elsevier Science |
| ISSN: | 0168-1702 |
| Published Online: | 28 January 2010 |
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