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Induction of apoptosis and inhibition of cellular proliferation as a dual approach to treatment of ovarian cancer

Edwards, J., and Bartlett, J.M.S. (1999) Induction of apoptosis and inhibition of cellular proliferation as a dual approach to treatment of ovarian cancer. International Journal of Oncology, 15 (3). pp. 583-588. ISSN 1019-6439

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Abstract

Inhibition of mitosis or induction of apoptosis are pathways at which anti tumour therapies could be aimed. This study evaluates the actions of CGP52411 (cell growth inhibitor) and transforming growth factor beta 1 (TGF beta 1) (inducer of apoptosis) alone and in combination on two ovarian carcinoma cell lines (PEO1 and OVCAR3). In both cell lines TGF beta 1 treatment increased the level of apoptotic cells and CGP52411 treatment reduced EGF stimulated cell growth. Combined treatment further reduced cell numbers in PEO1 cultures, demonstrating that dual therapy aimed at both aspects of cell regulation has a greater anti tumour action.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Edwards, Dr Joanne
Authors: Edwards, J., and Bartlett, J.M.S.
Subjects:R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:International Journal of Oncology
ISSN:1019-6439

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