Zhang, X.L., Yin, H.B. , Cooper, J.M. and Haswell, S.J. (2008) Characterization of cellular chemical dynamics using combined microfluidic and Raman techniques. Analytical and Bioanalytical Chemistry, 390(3), pp. 833-840. (doi: 10.1007/s00216-007-1564-9)
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Publisher's URL: http://dx.doi.org/10.1007/s00216-007-1564-9
Abstract
The integration of a range of technologies including microfluidics, surface-enhanced Raman scattering and confocal microspectroscopy has been successfully used to characterize in situ single living CHO (Chinese hamster ovary) cells with a high degree of spatial (in three dimensions) and temporal (1 s per spectrum) resolution. Following the introduction of a continuous flow of ionomycin, the real time spectral response from the cell was monitored during the agonist-evoked Ca2+ flux process. The methodology described has the potential to be used for the study of the cellular dynamics of a range of signalling processes
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Yin, Professor Huabing and Cooper, Professor Jonathan |
| Authors: | Zhang, X.L., Yin, H.B., Cooper, J.M., and Haswell, S.J. |
| College/School: | College of Science and Engineering > School of Engineering > Biomedical Engineering |
| Journal Name: | Analytical and Bioanalytical Chemistry |
| Journal Abbr.: | Anal. bioanal. chem. |
| ISSN: | 1618-2642 |
| ISSN (Online): | 1618-2650 |
| Published Online: | 12 September 2007 |
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