A high-throughput assay of cell-surface interactions using topographical and chemical gradients

Yang, J., Rose, F.R.A.J., Gadegaard, N. and Alexander, M. (2009) A high-throughput assay of cell-surface interactions using topographical and chemical gradients. Advanced Materials, 21(3), pp. 300-304. (doi:10.1002/adma.200801942)

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Publisher's URL: http://dx.doi.org/10.1002/adma.200801942

Abstract

Orthogonal wettability and topographical gradients in a combinatorial sample format are fabricated using plasma-polymer-coated microgrooved surfaces. Preferred 8 cell proliferation is found on specific combinations of topography and chemistry. This proof-of-concept study demonstrates the potential applications of this sample format for investigating the relationship between multiple surface properties on cellular response in a high-throughput manner

Item Type:Articles
Keywords:Allylamine, assay, attachment, behaviour, cell, cell-proliferation, chemical gradients, deposition, England, fibroblasts, micro, physics, plasma polymers, proliferation, science, surfaces, tissue-engineering scaffolds, topography, wettability
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Gadegaard, Professor Nikolaj
Authors: Yang, J., Rose, F.R.A.J., Gadegaard, N., and Alexander, M.
College/School:College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Advanced Materials
Publisher:Wiley - V C H Verlag GmbH & Co. KGaA
ISSN:0935-9648
ISSN (Online):1521-4095
Published Online:04 November 2008

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