Factors related to colonic fermentation of nondigestible carbohydrates of a previous evening meal increase tissue glucose uptake and moderate glucose-associated inflammation

Priebe, M.G., Wang, H.W., Weening, D., Schepers, M., Preston, T. and Vonk, R.J. (2010) Factors related to colonic fermentation of nondigestible carbohydrates of a previous evening meal increase tissue glucose uptake and moderate glucose-associated inflammation. American Journal of Clinical Nutrition, 91(1), pp. 90-97. (doi:10.3945/ajcn.2009.28521)

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Abstract

<b>Background</b>: Evening meals that are rich in nondigestible carbohydrates have been shown to lower postprandial glucose concentrations after ingestion of high-glycemic-index breakfasts. This phenomenon is linked to colonic fermentation of nondigestible carbohydrates, but the underlying mechanism is not fully elucidated. <b>Objective</b>: We examined the way in which glucose kinetics and related factors change after breakfast as a result of colonic fermentation. <b>Design</b>: In a crossover design, 10 healthy men ingested as an evening meal white wheat bread (WB) or cooked barley kernels (BA) that were rich in nondigestible carbohydrates. In the morning after intake of 50 g <sup>13</sup>C-enriched glucose, the dual-isotope technique was applied to determine glucose kinetics. Plasma insulin, free fatty acid, interleukin-6, tumor necrosis factor-{alpha}, and short-chain fatty acid concentrations and breath-hydrogen excretion were measured. <b>Results</b>: The plasma glucose response after the glucose drink was 29% lower after the BA evening meal (P = 0.019). The insulin response was the same, whereas mean (±SEM) tissue glucose uptake was 30% higher (20.2 ± 1.9 compared with 15.5 ± 1.8 mL/2 h; P = 0.016) after the BA evening meal, which indicated higher peripheral insulin sensitivity (P = 0.001). The 4-h mean postprandial interleukin-6 (19.7 ± 5.1 compared with 5.1 ± 0.7 pg/mL; P = 0.024) and tumor necrosis factor-α (7.8 ± 2.1 compared with 5.3 ± 1.6 pg/mL; P = 0.008) concentrations after the glucose drink were higher after the WB evening meal. Butyrate concentrations (P = 0.041) and hydrogen excretion (P = 0.005) were higher in the morning after the BA evening meal. <b>Conclusion</b>: In healthy subjects, factors related to colonic fermentation of nondigestible carbohydrates increase peripheral insulin sensitivity and moderate glucose-associated inflammation.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Preston, Professor Thomas
Authors: Priebe, M.G., Wang, H.W., Weening, D., Schepers, M., Preston, T., and Vonk, R.J.
Subjects:G Geography. Anthropology. Recreation > GE Environmental Sciences
Q Science > QP Physiology
College/School:College of Science and Engineering > Scottish Universities Environmental Research Centre
Journal Name:American Journal of Clinical Nutrition
ISSN:0002-9165
ISSN (Online):1938-3207
Published Online:04 November 2009

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