Genetic aberrations of NAT2 and chromosome 8: Their association with progression in transitional cell carcinoma of the urinary bladder

Watters, A.D., Stacey, M.W., Going, J.J., Grigor, K.M., Cooke, T.G., Sim, E. and Bartlett, J.M.S. (2001) Genetic aberrations of NAT2 and chromosome 8: Their association with progression in transitional cell carcinoma of the urinary bladder. Urologia Internationalis, 67(3), pp. 235-239. (doi: 10.1159/000050995)

Abstract

Introduction/Objective: N-acetyltransferase 2 (NAT2), mapped to 8p22, is a polymorphic enzyme which metabolizes aromatic amines. Loss of heterozygosity of 8p22 is associated with an increased risk of bladder cancer. This study evaluated NAT2 and chromosome 8 in sequential tumours from bladder cancer patients to determine if NAT2 alterations increase the risk of progression. Materials and Methods: Thirty-seven sequential carcinomas from 19 patients were assessed using fluorescence in situ hybridization. Results: Five carcinomas showed loss of NAT2; 4 of these were from pTa/pT1 tumours. Polysomy 8 was observed in 4 of 14 (29%) primary carcinomas (pTa/pT1), in 4 of 12 (33%) pTa/pT1 recurrences, and in 90% (9/10) of the detrusor muscle invasive tumours (pT2+). 6 of 8 (75%) locally invasive tumours with polysomy 8 were from patients who subsequently developed disease progression (pT2+). In total, 13.5% (5/37) of the carcinomas were abnormal for NAT2, and 46% (17/37) were abnormal for chromosome 8 copy number. Polysomy 8 was associated with high grade (p = 0.01) and stage (p = 0.03) and disease progression (p = 0.03). Conclusion: Whilst there does not appear to be an association between loss of NAT2 and risk of progression in transitional cell carcinoma, the high rate of polysomy of chromosome 8 implies that other genes on this chromosome significantly influence disease progression.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Going, Dr James and Cooke, Prof Timothy
• Authors: Watters, A.D., Stacey, M.W., Going, J.J., Grigor, K.M., Cooke, T.G., Sim, E., and Bartlett, J.M.S.
• Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer); R Medicine > RB Pathology
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Urologia Internationalis
• ISSN: 0042-1138