G protein-coupled receptor dimerisation: molecular basis and relevance to function

Milligan, G. (2007) G protein-coupled receptor dimerisation: molecular basis and relevance to function. Biochimica et Biophysica Acta: Biomembranes, 1768(4), pp. 825-835. (doi: 10.1016/j.bbamem.2006.09.021)

Abstract

The belief that G protein-coupled receptors exist and function as monomeric, non-interacting species has been largely supplanted in recent years by evidence, derived from a range of approaches, that indicate they can form dimers and/or higher-order oligomeric complexes. Key roles for receptor homo-dimerisation include effective quality control of protein folding prior to plasma membrane delivery and interactions with hetero-trimeric G proteins. Growing evidence has also indicated the potential for many co-expressed G protein-coupled receptors to form hetero-dimers/oligomers. The relevance of this to physiology and function is only beginning to be unravelled but may offer great potential for more selective therapeutic intervention.

• Item Type: Articles
• Keywords: G protein-coupled receptor, dimerisation, signal transduction.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Milligan, Professor Graeme
• Authors: Milligan, G.
• College/School: College of Medical Veterinary and Life Sciences; College of Medical Veterinary and Life Sciences > School of Molecular Biosciences
• Journal Name: Biochimica et Biophysica Acta: Biomembranes
• Publisher: Elsevier
• ISSN: 0005-2736
• Published Online: 30 September 2006
• Copyright Holders: Copyright © 2007 Elsevier
• First Published: First published in Biochimica et Biophysica Acta (BBA) Biomembranes 1768(4):825-835
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher.

Related URLs

• PubMed

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
24249	1	Quantitative Analysis of the Effects of Receptor and G-Protein Mutations and Polymorphisms on Signal Initiation	Graeme Milligan	Medical Research Council (MRC)	G9811527	Institute of Neuroscience and Psychology
24249	2	Quantitative Analysis of the Effects of Receptor and G-Protein Mutations and Polymorphisms on Signal Initiation	Graeme Milligan	Medical Research Council (MRC)	G9811527	Institute of Neuroscience and Psychology
38978	1	The quaternary structure of G-protein coupled receptors - implications for function drug design. Programme grant support renewal	Graeme Milligan	Medical Research Council (MRC)	G9811527	Institute of Neuroscience and Psychology