G protein-coupled receptor dimerisation: molecular basis and relevance to function

Milligan, G. (2007) G protein-coupled receptor dimerisation: molecular basis and relevance to function. Biochimica et Biophysica Acta: Biomembranes, 1768(4), pp. 825-835. (doi: 10.1016/j.bbamem.2006.09.021)



Publisher's URL: http://dx.doi.org/doi:10.1016/j.bbamem.2006.09.021


The belief that G protein-coupled receptors exist and function as monomeric, non-interacting species has been largely supplanted in recent years by evidence, derived from a range of approaches, that indicate they can form dimers and/or higher-order oligomeric complexes. Key roles for receptor homo-dimerisation include effective quality control of protein folding prior to plasma membrane delivery and interactions with hetero-trimeric G proteins. Growing evidence has also indicated the potential for many co-expressed G protein-coupled receptors to form hetero-dimers/oligomers. The relevance of this to physiology and function is only beginning to be unravelled but may offer great potential for more selective therapeutic intervention.

Item Type:Articles
Keywords:G protein-coupled receptor, dimerisation, signal transduction.
Glasgow Author(s) Enlighten ID:Milligan, Professor Graeme
Authors: Milligan, G.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Biochimica et Biophysica Acta: Biomembranes
Published Online:30 September 2006
Copyright Holders:Copyright © 2007 Elsevier
First Published:First published in Biochimica et Biophysica Acta (BBA) Biomembranes 1768(4):825-835
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher.
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