Bakker, B., Krauth-Siegel, R.L., Clayton, C., Matthews, K., Girolami, M., Westerhoff, H.V., Michels, P.A.M., Breitling, R. and Barrett, M.P. (2010) The silicon trypanosome. Parasitology, 137(9), pp. 1333-1341. (doi: 10.1017/S0031182010000466) (PMID:20444304)
![[img]](https://eprints.gla.ac.uk/style/images/fileicons/text.png) |
Text
34092.pdf 238kB |
Abstract
African trypanosomes have emerged as promising unicellular model organisms for the next generation of systems biology. They offer unique advantages, due to their relative simplicity, the availability of all standard genomics techniques and a long history of quantitative research. Reproducible cultivation methods exist for morphologically and physiologically distinct life-cycle stages. The genome has been sequenced, and microarrays, RNA-interference and high-accuracy metabolomics are available. Furthermore, the availability of extensive kinetic data on all glycolytic enzymes has led to the early development of a complete, experiment-based dynamic model of an important biochemical pathway. Here we describe the achievements of trypanosome systems biology so far and outline the necessary steps towards the ambitious aim of creating a , a comprehensive, experiment-based, multi-scale mathematical model of trypanosome physiology. We expect that, in the long run, the quantitative modelling enabled by the Silicon Trypanosome will play a key role in selecting the most suitable targets for developing new anti-parasite drugs.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Breitling, Professor Rainer and Barrett, Professor Michael and Girolami, Prof Mark |
| Authors: | Bakker, B., Krauth-Siegel, R.L., Clayton, C., Matthews, K., Girolami, M., Westerhoff, H.V., Michels, P.A.M., Breitling, R., and Barrett, M.P. |
| Subjects: | Q Science > QR Microbiology |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Molecular Biosciences College of Science and Engineering > School of Computing Science |
| Journal Name: | Parasitology |
| Publisher: | Cambridge University Press |
| ISSN: | 0031-1820 |
| ISSN (Online): | 1469-8161 |
| Published Online: | 06 May 2010 |
| Copyright Holders: | Copyright © 2010 Cambridge University Press |
| First Published: | First published in Parasitology 137(9):1333-1341 |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
University Staff: Request a correction | Enlighten Editors: Update this record
Funder and Project Information
Funder and Project Information